Homologous recombination pathway

URI: https://gptkb.org/entity/Homologous_recombination_pathway
GPTKB entity
Statements (43)
Predicate Object
gptkbp:instanceOf gptkb:biological_pathway
gptkbp:activeDuring gptkb:S_phase
G2 phase
gptkbp:alternativeTo gptkb:non-homologous_end_joining
gptkbp:defect_causes genomic instability
cancer predisposition
gptkbp:firstDescribed Robin Holliday
gptkbp:function DNA repair
maintenance of genome stability
genetic recombination
gptkbp:importantFor meiosis
mitosis
gptkbp:inhibitedBy gptkb:53BP1
gptkbp:involves DNA synthesis
homologous recombination
resolution of Holliday junctions
Holliday junction formation
branch migration
strand invasion
gptkbp:key_protein gptkb:RPA
gptkb:NBS1
gptkb:BRCA1
gptkb:BRCA2
gptkb:RAD51
gptkb:RAD52
gptkb:MRE11
gptkb:ATM
RecA
gptkbp:launched DNA end resection
gptkbp:occurredIn prokaryotes
eukaryotes
gptkbp:regulates cell cycle
gptkbp:relatedTo crossing over
gene conversion
gptkbp:repairs double-strand DNA breaks
stalled replication forks
gptkbp:studiedBy gptkb:yeast
gptkb:Bacteria
mammals
gptkbp:target PARP inhibitors
gptkbp:bfsParent gptkb:ENSG00000120656
gptkbp:bfsLayer 8
https://www.w3.org/2000/01/rdf-schema#label Homologous recombination pathway