Homologous recombination pathway
GPTKB entity
Statements (43)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
biological pathway
|
| gptkbp:activeDuring |
gptkb:S_phase
G2 phase |
| gptkbp:alternativeTo |
gptkb:non-homologous_end_joining
|
| gptkbp:defect_causes |
genomic instability
cancer predisposition |
| gptkbp:firstDescribed |
Robin Holliday
|
| gptkbp:function |
DNA repair
maintenance of genome stability genetic recombination |
| https://www.w3.org/2000/01/rdf-schema#label |
Homologous recombination pathway
|
| gptkbp:importantFor |
meiosis
mitosis |
| gptkbp:inhibitedBy |
gptkb:53BP1
|
| gptkbp:involves |
DNA synthesis
homologous recombination resolution of Holliday junctions Holliday junction formation branch migration strand invasion |
| gptkbp:key_protein |
gptkb:RPA
gptkb:NBS1 gptkb:BRCA1 gptkb:BRCA2 gptkb:RAD51 gptkb:RAD52 gptkb:MRE11 ATM RecA |
| gptkbp:launched |
DNA end resection
|
| gptkbp:occurredIn |
prokaryotes
eukaryotes |
| gptkbp:regulates |
cell cycle
|
| gptkbp:relatedTo |
crossing over
gene conversion |
| gptkbp:repairs |
double-strand DNA breaks
stalled replication forks |
| gptkbp:studiedBy |
gptkb:yeast
gptkb:Bacteria mammals |
| gptkbp:target |
PARP inhibitors
|
| gptkbp:bfsParent |
gptkb:ENSG00000120656
|
| gptkbp:bfsLayer |
8
|