|
gptkbp:instanceOf
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gptkb:protein
gptkb:G_protein-coupled_receptor
|
|
gptkbp:alternativeName
|
gptkb:HRH4
H4R
histamine receptor H4
|
|
gptkbp:associatedWith
|
asthma
autoimmune diseases
pruritus
allergic inflammation
|
|
gptkbp:binds
|
gptkb:histamine
|
|
gptkbp:biologicalProcess
|
G protein-coupled receptor activity
histamine receptor activity
|
|
gptkbp:discoveredIn
|
2000
|
|
gptkbp:encodedBy
|
gptkb:HRH4_gene
|
|
gptkbp:enemyOf
|
A-940894
4-methylhistamine
JNJ 7777120
VUF 8430
|
|
gptkbp:Entrez_Gene_ID
|
59340
|
|
gptkbp:expressedIn
|
gptkb:T_cells
gptkb:thymus
gptkb:basophils
gptkb:mast_cells
gptkb:eosinophils
spleen
bone marrow
dendritic cells
monocytes
|
|
gptkbp:foundIn
|
gptkb:human
gptkb:mouse
right
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Histamine H4 receptor
|
|
gptkbp:involvedIn
|
inflammation
immune response
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_18q11.2
|
|
gptkbp:OMIM
|
606933
|
|
gptkbp:orthologIn
|
mouse Hrh4
rat Hrh4
|
|
gptkbp:regulates
|
cytokine production
mast cell activation
chemotaxis of immune cells
|
|
gptkbp:subclassOf
|
antihistamine
class A rhodopsin-like GPCR
|
|
gptkbp:target
|
drug development for allergy
drug development for inflammation
drug development for pruritus
|
|
gptkbp:UniProtID
|
gptkb:Q9H3N8
|
|
gptkbp:bfsParent
|
gptkb:H4_receptor
gptkb:HRH4_gene
|
|
gptkbp:bfsLayer
|
7
|