|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:abnormalExpressionLeadsTo
|
malformations
|
|
gptkbp:binds
|
gptkb:gene
|
|
gptkbp:clustersInHuman
|
gptkb:HOXA
gptkb:HOXB
gptkb:HOXC
gptkb:HOXD
|
|
gptkbp:discoveredIn
|
gptkb:Drosophila_melanogaster
|
|
gptkbp:domain
|
homeodomain
|
|
gptkbp:encodedBy
|
gptkb:HOX_genes
|
|
gptkbp:evolutionaryConservation
|
high
|
|
gptkbp:expressedIn
|
specific body segments
|
|
gptkbp:firstDescribed
|
gptkb:Edward_B._Lewis
|
|
gptkbp:foundIn
|
animals
|
|
gptkbp:function
|
transcription factor
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
HOX proteins
|
|
gptkbp:interactsWith
|
cofactors
|
|
gptkbp:involvedIn
|
morphogenesis
|
|
gptkbp:involves
|
gptkb:cancer
leukemia
congenital malformations
limb defects
spinal cord defects
|
|
gptkbp:mutationAssociatedWith
|
developmental disorders
|
|
gptkbp:numberOfGenes
|
39
|
|
gptkbp:organizedBy
|
clusters
|
|
gptkbp:orthologIn
|
gptkb:ANTP-class_homeobox_proteins
gptkb:yeast
fungi
plants
|
|
gptkbp:presentIn
|
invertebrates
vertebrates
|
|
gptkbp:regulates
|
gptkb:migration
apoptosis
cell proliferation
differentiation
gene expression
angiogenesis
organogenesis
cell fate
neural development
segment identity
hematopoiesis
urogenital system development
anterior-posterior axis formation
limb development
adhesion
gastrointestinal tract development
reproductive system development
skeletal patterning
|
|
gptkbp:relatedTo
|
homeobox genes
|
|
gptkbp:role
|
embryonic development
body patterning
|
|
gptkbp:studiedIn
|
model organisms
|
|
gptkbp:bfsParent
|
gptkb:Pre-B-cell_leukemia_homeobox_protein
|
|
gptkbp:bfsLayer
|
6
|