HMG CoA reductase inhibitors (statins)

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:drug
gptkbp:alsoKnownAs	statins
gptkbp:approvedBy	1987
gptkbp:ATCCode	gptkb:C10AA
gptkbp:contraindication	pregnancy active liver disease
gptkbp:discoveredBy	gptkb:Akira_Endo
gptkbp:drugInteraction	gptkb:fibrates CYP3A4 inhibitors
gptkbp:effect	lower LDL cholesterol lower triglycerides modest increase in HDL cholesterol
gptkbp:effectOnMortality	reduces all-cause mortality in high-risk patients reduces cardiovascular mortality
gptkbp:example	gptkb:pitavastatin gptkb:atorvastatin gptkb:pravastatin gptkb:rosuvastatin gptkb:lovastatin gptkb:simvastatin gptkb:fluvastatin
gptkbp:hasApprovedDrug	gptkb:lovastatin
https://www.w3.org/2000/01/rdf-schema#label	HMG CoA reductase inhibitors (statins)
gptkbp:indication	gptkb:familial_hypercholesterolemia prevention of cardiovascular events
gptkbp:mechanismOfAction	inhibit HMG-CoA reductase
gptkbp:metabolism	liver
gptkbp:pregnancyCategory	X
gptkbp:prescriptionStatus	prescription only
gptkbp:primaryUse	lower cholesterol reduce cardiovascular risk
gptkbp:routeOfAdministration	oral
gptkbp:sideEffect	gastrointestinal upset muscular dystrophy rhabdomyolysis liver enzyme elevation
gptkbp:WHOModelListOfEssentialMedicines	yes
gptkbp:bfsParent	gptkb:C10AA
gptkbp:bfsLayer	7