Statements (44)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
biological pathway
|
| gptkbp:alsoKnownAs |
HMG-CoA reductase pathway
|
| gptkbp:associatedWith |
gptkb:familial_hypercholesterolemia
mevalonate kinase deficiency mevalonic aciduria |
| gptkbp:discoveredBy |
gptkb:Feodor_Lynen
gptkb:Konrad_Bloch |
| gptkbp:foundIn |
archaea
eukaryotes some bacteria |
| https://www.w3.org/2000/01/rdf-schema#label |
mevalonate pathway
|
| gptkbp:importantFor |
critical for steroid biosynthesis
important in cancer biology target for cholesterol-lowering drugs |
| gptkbp:inhibitedBy |
statins
|
| gptkbp:keyEnzyme |
gptkb:HMG-CoA_reductase
mevalonate kinase mevalonate-5-pyrophosphate decarboxylase phosphomevalonate kinase |
| gptkbp:location |
gptkb:peroxisome
cytosol |
| gptkbp:NobelPrizeYear |
gptkb:Nobel_Prize_in_Physiology_or_Medicine_1964
|
| gptkbp:produces |
cholesterol
ubiquinone dolichol isoprenoids prenylated proteins |
| gptkbp:regulates |
feedback inhibition by cholesterol
regulated by SREBP |
| gptkbp:relatedTo |
non-mevalonate pathway
|
| gptkbp:requires |
cell membrane synthesis
hormone synthesis protein prenylation |
| gptkbp:step |
mevalonate-5-pyrophosphate to isopentenyl pyrophosphate
HMG-CoA to mevalonate acetyl-CoA to HMG-CoA mevalonate to mevalonate-5-phosphate mevalonate-5-phosphate to mevalonate-5-pyrophosphate |
| gptkbp:substrate |
gptkb:HMG-CoA
acetyl-CoA |
| gptkbp:bfsParent |
gptkb:HMG-CoA_reductase
gptkb:geranyl_pyrophosphate gptkb:Astaxanthin |
| gptkbp:bfsLayer |
7
|