HLA-DRA

GPTKB entity

Statements (51)
Predicate Object
gptkbp:instanceOf gptkb:gene
gptkbp:alternativeName MHC class II, DR alpha
HLA class II histocompatibility antigen, DR alpha chain
gptkbp:associatedWith type 1 diabetes
autoimmune diseases
rheumatoid arthritis
gptkbp:discoveredBy histocompatibility studies
gptkbp:disulfideBond present
gptkbp:encodes HLA class II histocompatibility antigen, DR alpha chain
gptkbp:Entrez_Gene_ID 3122
gptkbp:expressedIn antigen-presenting cells
gptkbp:formsComplexWith gptkb:HLA-DRB1
gptkbp:formsHeterodimerWith gptkb:HLA-DRB1
gptkbp:foundIn gptkb:cell_membrane
gptkbp:function antigen presentation
gptkbp:geneType protein-coding
gptkbp:glycosylation present
gptkbp:has3PrimeUTR present
gptkbp:has5PrimeUTR present
gptkbp:hasAllele HLA-DRA*01:01
HLA-DRA*01:02
gptkbp:hasPromoter present
gptkbp:hasProteinLength 254 amino acids
gptkbp:hasPseudogene HLA-DRAX
gptkbp:hasTranscriptVariant NM_002124
NM_019111
gptkbp:HGNC_ID 4948
https://www.w3.org/2000/01/rdf-schema#label HLA-DRA
gptkbp:involvedIn immune response
gptkbp:isHighlyConserved yes
gptkbp:locatedOnChromosome gptkb:6p21.3
gptkb:chromosome_6
gptkbp:molecularWeight 29 kDa
gptkbp:numberOfExons 5
gptkbp:OMIM 142860
gptkbp:orthologInMouse H2-Aa
gptkbp:partOf gptkb:major_histocompatibility_complex
gptkb:HLA-DR
gptkbp:product HLA-DRA protein
gptkbp:proteinFamily immunoglobulin-like domain
HLA class II alpha chain paralogs
gptkbp:referenceGenome NC_000006.12
gptkbp:regulates gptkb:CIITA
gptkb:CREB1
RFX5
gptkbp:signalPeptide present
gptkbp:species gptkb:Homo_sapiens
gptkbp:transmembraneDomains present
gptkbp:UniProtID P01903
gptkbp:bfsParent gptkb:DR1A
gptkbp:bfsLayer 7