|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:affiliatedWith
|
gptkb:HLA_class_II_genes
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
multiple sclerosis
type 1 diabetes
autoimmune diseases
rheumatoid arthritis
|
|
gptkbp:biologicalProcess
|
gptkb:immune_response
MHC class II receptor activity
|
|
gptkbp:discoveredIn
|
1970s
|
|
gptkbp:encodes
|
HLA-DR beta 1 chain protein
|
|
gptkbp:Entrez_Gene_ID
|
3123
ENSG00000196126
|
|
gptkbp:expressedIn
|
gptkb:B_cells
dendritic cells
macrophages
immune cells
antigen-presenting cells
|
|
gptkbp:function
|
antigen presentation
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:hasAllele
|
HLA-DRB1*01:01
HLA-DRB1*04:01
HLA-DRB1*15:01
|
|
gptkbp:hasCellularComponent
|
MHC class II protein complex
|
|
gptkbp:hasPolymorphism
|
yes
|
|
gptkbp:hasPseudogene
|
gptkb:HLA-DRB5
HLA-DRB3
HLA-DRB4
HLA-DRB2
HLA-DRB6
HLA-DRB9
|
|
gptkbp:hasRefSeqID
|
NM_002124
NP_002115
|
|
gptkbp:HGNC_ID
|
4948
|
|
gptkbp:involvedIn
|
adaptive immune response
|
|
gptkbp:length
|
over 10 kb
|
|
gptkbp:locatedIn
|
gptkb:6p21.3
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_6
|
|
gptkbp:numberOfExons
|
6
|
|
gptkbp:OMIM
|
142857
|
|
gptkbp:orthologIn
|
mouse H2-Ab1
|
|
gptkbp:partOf
|
gptkb:major_histocompatibility_complex
gptkb:HLA-DR
|
|
gptkbp:product
|
HLA class II histocompatibility antigen, DRB1 beta chain
|
|
gptkbp:proteinFamily
|
HLA-DRB
|
|
gptkbp:significance
|
organ transplantation
pharmacogenomics
disease susceptibility
|
|
gptkbp:UniProtID
|
P04229
|
|
gptkbp:bfsParent
|
gptkb:6p21.31
gptkb:6p21.32
gptkb:DRB1*0801
gptkb:DRB1*0804
gptkb:DRB1*0810
gptkb:DRB1*0812
gptkb:DRB1*0814
gptkb:DRB1*0815
gptkb:DRB1*0818
gptkb:DRB1*0820
gptkb:DRB1*0821
gptkb:DRB1*0824
gptkb:DRB1*0825
gptkb:DRB1*0826
gptkb:DRB1*0827
gptkb:DRB1*0828
gptkb:DRB1*0829
gptkb:DRB1*0832
gptkb:DRB1*0836
gptkb:DRB1*0837
gptkb:DRB1*0839
gptkb:DRB1*0844
gptkb:DRB1*0848
gptkb:DRB1*0849
gptkb:DRB1*0850
gptkb:HLA-DRB1*04_allele
gptkb:HLA-DR_gene
|
|
gptkbp:bfsLayer
|
8
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
HLA-DRB1
|