Statements (113)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:gene
|
| gptkbp:alias |
gptkb:CYP2D
gptkb:CYP2D7AP gptkb:P450DB1 gptkb:CPD6 P450C2D cytochrome P450, debrisoquine 4-hydroxylase |
| gptkbp:approvedBy |
gptkb:cytochrome_P450_family_2_subfamily_D_member_6
|
| gptkbp:approvedSymbol |
gptkb:CYP2D6
|
| gptkbp:associatedWith |
drug overdose
pharmacogenomics personalized medicine drug addiction drug resistance drug dependence drug abuse drug safety drug withdrawal drug-induced lupus adverse drug reactions drug-induced liver injury drug-induced toxicity drug interaction ultrarapid metabolizer phenotype antidepressant metabolism antipsychotic metabolism codeine toxicity opioid metabolism tamoxifen metabolism debrisoquine metabolism drug response variability drug efficacy pharmacogenetic variability SSRIs metabolism adverse drug event anticonvulsant metabolism antifungal metabolism antihistamine metabolism antihypertensive metabolism antimalarial metabolism antimigraine metabolism antineoplastic metabolism antiparkinsonian metabolism antipsychotic-induced side effects antiviral metabolism beta-blocker metabolism dextromethorphan metabolism drug hypersensitivity drug intolerance drug metabolism disorder drug misuse drug-gene interaction drug-induced Stevens-Johnson syndrome drug-induced agranulocytosis drug-induced anaphylaxis drug-induced angioedema drug-induced aplastic anemia drug-induced autoimmune disease drug-induced bone marrow suppression drug-induced carcinogenicity drug-induced cardiotoxicity drug-induced erythema multiforme drug-induced hematotoxicity drug-induced hemolytic anemia drug-induced hypersensitivity drug-induced immunosuppression drug-induced immunotoxicity drug-induced leukopenia drug-induced mutagenicity drug-induced myelosuppression drug-induced nephrotoxicity drug-induced neurotoxicity drug-induced neutropenia drug-induced pancytopenia drug-induced photosensitivity drug-induced pruritus drug-induced rash drug-induced teratogenicity drug-induced thrombocytopenia drug-induced toxic epidermal necrolysis drug-induced urticaria drug-induced vasculitis extensive metabolizer phenotype intermediate metabolizer phenotype metoprolol metabolism nortriptyline metabolism poor drug metabolism phenotype tricyclic antidepressant metabolism |
| gptkbp:Entrez_Gene_ID |
gptkb:ENSG00000100197
1565 |
| gptkbp:function |
drug metabolism
oxidation of xenobiotics |
| gptkbp:HGNC_ID |
gptkb:HGNC:2247
|
| https://www.w3.org/2000/01/rdf-schema#label |
HGNC:2247
|
| gptkbp:locatedOnChromosome |
22
|
| gptkbp:location |
gptkb:22q13.2
|
| gptkbp:locusType |
gptkb:gene
gene with protein product |
| gptkbp:OMIM |
124030
|
| gptkbp:organism |
gptkb:Homo_sapiens
|
| gptkbp:previousName |
gptkb:debrisoquine_4-hydroxylase
gptkb:cytochrome_P450,_subfamily_IID,_polypeptide_1 |
| gptkbp:previousSymbols |
gptkb:CYP2D
gptkb:P450DB1 |
| gptkbp:proteinFamily |
gptkb:cytochrome_P450
gptkb:CYP2D_subfamily |
| gptkbp:RefSeq |
gptkb:NM_000106
|
| gptkbp:status |
Approved
|
| gptkbp:ucscId |
uc003bqg.4
|
| gptkbp:UniProtID |
P10635
|
| gptkbp:vegaId |
OTTHUMG00000183507
|
| gptkbp:bfsParent |
gptkb:P31040
|
| gptkbp:bfsLayer |
8
|