Statements (32)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
antihistamine |
| gptkbp:activatedBy |
gptkb:histamine
|
| gptkbp:associatedWith |
gptkb:Zollinger-Ellison_syndrome
gptkb:gastroesophageal_reflux_disease peptic ulcer |
| gptkbp:discoveredBy |
gptkb:James_Black
|
| gptkbp:discoveredIn |
1972
|
| gptkbp:effect |
increases heart rate
increases gastric acid secretion relaxes vascular smooth muscle |
| gptkbp:encodedBy |
gptkb:HRH2_gene
|
| gptkbp:enemyOf |
gptkb:betazole
gptkb:dimaprit gptkb:impromidine gptkb:roxatidine gptkb:famotidine gptkb:ranitidine gptkb:nizatidine cimetidine |
| gptkbp:foundIn |
gptkb:gastric_parietal_cells
heart uterus vascular smooth muscle |
| gptkbp:function |
stimulates cAMP production
mediates gastric acid secretion |
| https://www.w3.org/2000/01/rdf-schema#label |
H2 receptor
|
| gptkbp:locatedOnChromosome |
gptkb:chromosome_5q35.2
|
| gptkbp:recipient |
gptkb:G_protein-coupled_receptor
|
| gptkbp:type |
Gs protein pathway
|
| gptkbp:bfsParent |
gptkb:antihistamine
|
| gptkbp:bfsLayer |
6
|