Statements (53)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:drug
|
| gptkbp:alsoKnownAs |
antihistamines
|
| gptkbp:availableOn |
over-the-counter
prescription |
| gptkbp:book |
do not cross blood-brain barrier significantly
less sedating |
| gptkbp:contraindication |
narrow-angle glaucoma
prostatic hypertrophy asthma (caution) |
| gptkbp:discoveredBy |
1940s
|
| gptkbp:drugInteraction |
gptkb:beer
gptkb:CNS_depressants |
| gptkbp:example |
gptkb:cetirizine
gptkb:loratadine gptkb:promethazine gptkb:azelastine gptkb:fexofenadine diphenhydramine chlorpheniramine clemastine hydroxyzine meclizine |
| gptkbp:excretion |
kidneys
|
| gptkbp:firstBook |
cross blood-brain barrier
|
| gptkbp:generation |
first-generation
second-generation |
| https://www.w3.org/2000/01/rdf-schema#label |
H1 antagonists
|
| gptkbp:mechanismOfAction |
block histamine H1 receptors
|
| gptkbp:metabolism |
liver
|
| gptkbp:pregnancyCategory |
varies by drug
|
| gptkbp:regulates |
gptkb:FDA
|
| gptkbp:routeOfAdministration |
oral
topical intranasal ophthalmic |
| gptkbp:sideEffect |
constipation
blurred vision drowsiness sedation dry mouth urinary retention |
| gptkbp:target |
antihistamine
|
| gptkbp:usedFor |
nausea
vomiting pruritus insomnia allergic rhinitis urticaria motion sickness allergic conjunctivitis anaphylaxis (adjunct) |
| gptkbp:bfsParent |
gptkb:H1_receptor
|
| gptkbp:bfsLayer |
7
|