Guanine nucleotide Exchange Factor
GPTKB entity
Statements (29)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:abbreviation |
gptkb:GEF
|
| gptkbp:discoveredIn |
1980s
|
| gptkbp:example |
gptkb:Dbl
gptkb:Epac gptkb:Vav gptkb:SOS1 Sec7 domain-containing proteins |
| gptkbp:foundIn |
eukaryotic cells
|
| gptkbp:function |
activates small GTPases
|
| https://www.w3.org/2000/01/rdf-schema#label |
Guanine nucleotide Exchange Factor
|
| gptkbp:mechanismOfAction |
promotes exchange of GDP for GTP
|
| gptkbp:opposedBy |
gptkb:GTPase-activating_protein_(GAP)
|
| gptkbp:regulates |
cell differentiation
vesicle trafficking cell growth cell migration cell signaling pathways cytoskeletal organization |
| gptkbp:relatedTo |
gptkb:cancer
neurological disorders immune response |
| gptkbp:target |
gptkb:Ran_family_GTPases
Arf family GTPases Rab family GTPases Ras family GTPases Rho family GTPases |
| gptkbp:bfsParent |
gptkb:GEF
|
| gptkbp:bfsLayer |
6
|