|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:alternativeName
|
gptkb:GPx
gptkb:GSH_peroxidase
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:cardiovascular_disease
gptkb:Keshan_disease
|
|
gptkbp:catalyzes
|
reduction of hydrogen peroxide
reduction of organic hydroperoxides
|
|
gptkbp:cofactor
|
gptkb:selenocysteine
|
|
gptkbp:discoveredBy
|
gptkb:G._Rotruck_et_al.
|
|
gptkbp:discoveredIn
|
1973
|
|
gptkbp:EC_number
|
1.11.1.9
|
|
gptkbp:expressedIn
|
gptkb:thyroid
gptkb:cancer
gptkb:skeletal_muscle
gptkb:kidney
gptkb:placenta
gptkb:testis
brain
heart
gastrointestinal tract
liver
erythrocytes
|
|
gptkbp:family
|
peroxidase
|
|
gptkbp:foundIn
|
gptkb:Bacteria
animals
plants
|
|
gptkbp:function
|
protects cells from oxidative damage
|
|
gptkbp:gene
|
gptkb:GPX
|
|
gptkbp:GO_term
|
GO:0004602
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Glutathione peroxidase
|
|
gptkbp:human_isoforms
|
gptkb:GPX1
gptkb:GPX2
gptkb:GPX3
gptkb:GPX4
gptkb:GPX5
gptkb:GPX6
gptkb:GPX7
gptkb:GPX8
|
|
gptkbp:inhibitedBy
|
gptkb:poisoning
mercury
|
|
gptkbp:molecular_weight_(GPX1)
|
~22 kDa
|
|
gptkbp:presentIn
|
mitochondria
cytosol
extracellular space
|
|
gptkbp:product
|
gptkb:water
gptkb:oxidized_glutathione
|
|
gptkbp:requires
|
selenium
|
|
gptkbp:structure
|
tetrameric protein (for GPX1)
|
|
gptkbp:substrate
|
glutathione
|
|
gptkbp:UniProt_ID_(GPX1)
|
P07203
|
|
gptkbp:bfsParent
|
gptkb:Enzymes
|
|
gptkbp:bfsLayer
|
6
|