Statements (49)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:gene
|
| gptkbp:alias |
GSHPx-3
plasma glutathione peroxidase |
| gptkbp:associatedWith |
gptkb:cancer
gptkb:diabetes hypertension oxidative stress |
| gptkbp:biologicalProcess |
cellular response to oxidative stress
glutathione peroxidase activity |
| gptkbp:cellularComponent |
extracellular region
|
| gptkbp:cofactor |
gptkb:selenocysteine
|
| gptkbp:discoveredBy |
1980s
|
| gptkbp:encodes |
glutathione peroxidase 3 protein
|
| gptkbp:Entrez_Gene_ID |
2878
ENSG00000211445 |
| gptkbp:expressedIn |
gptkb:thyroid
gptkb:cancer gptkb:plasma gptkb:kidney heart liver |
| gptkbp:fullName |
glutathione peroxidase 3
|
| gptkbp:function |
antioxidant enzyme
protects cells from oxidative damage reduces hydrogen peroxide |
| gptkbp:geneType |
protein-coding
|
| gptkbp:HGNC_ID |
HGNC:4554
|
| https://www.w3.org/2000/01/rdf-schema#label |
GPX3
|
| gptkbp:length |
226 amino acids
|
| gptkbp:locatedOnChromosome |
5q33.1
|
| gptkbp:mRNA |
transcribed in kidney
|
| gptkbp:mutationAssociatedWith |
may increase risk of certain cancers
|
| gptkbp:OMIM |
138322
|
| gptkbp:organism |
gptkb:Homo_sapiens
|
| gptkbp:orthologInMouse |
Gpx3
|
| gptkbp:pathway |
detoxification of reactive oxygen species
glutathione metabolism |
| gptkbp:PDB |
2R37
|
| gptkbp:proteinFamily |
glutathione peroxidase family
|
| gptkbp:proteinSecretion |
secreted into plasma
|
| gptkbp:RefSeq |
NM_002084
|
| gptkbp:regulates |
regulated by oxidative stress
|
| gptkbp:significance |
biomarker for oxidative stress
potential tumor suppressor |
| gptkbp:tissue_specificity |
high in kidney
present in plasma |
| gptkbp:UniProtID |
P22352
|
| gptkbp:bfsParent |
gptkb:Glutathione_peroxidase
|
| gptkbp:bfsLayer |
7
|