|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alias
|
GSHPx-4
PHGPx
glutathione peroxidase, phospholipid hydroperoxide
|
|
gptkbp:associatedWith
|
Spondylometaphyseal dysplasia, Sedaghatian type
|
|
gptkbp:cofactor
|
gptkb:selenocysteine
|
|
gptkbp:discoveredBy
|
1989
|
|
gptkbp:Entrez_Gene_ID
|
2879
ENSG00000167468
|
|
gptkbp:enzymeClassification
|
EC 1.11.1.12
|
|
gptkbp:expressedIn
|
gptkb:kidney
gptkb:testis
brain
heart
liver
|
|
gptkbp:fullName
|
Glutathione peroxidase 4
|
|
gptkbp:function
|
protects cells against oxidative damage
reduces lipid hydroperoxides to alcohols
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:hasTranscriptVariant
|
multiple
|
|
gptkbp:HGNC_ID
|
4554
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
GPX4
|
|
gptkbp:inhibitedBy
|
FIN56
ML162
RSL3
|
|
gptkbp:locatedOnChromosome
|
gptkb:19p13.3
|
|
gptkbp:location
|
gptkb:nucleus
gptkb:cytoplasm
mitochondrion
|
|
gptkbp:molecularWeight
|
22 kDa
|
|
gptkbp:mutationAssociatedWith
|
embryonic lethality in mice
|
|
gptkbp:numberOfExons
|
7
|
|
gptkbp:OMIM
|
602674
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
Gpx4
|
|
gptkbp:pathway
|
glutathione metabolism
reactive oxygen species detoxification
lipid peroxidation
|
|
gptkbp:PDB
|
2GS3
2OBI
|
|
gptkbp:RefSeq
|
NM_002085
|
|
gptkbp:regulates
|
selenium-dependent
|
|
gptkbp:relatedTo
|
apoptosis
antioxidant defense
ferroptosis
|
|
gptkbp:requires
|
embryonic development
male fertility
|
|
gptkbp:UniProtID
|
P36969
|
|
gptkbp:bfsParent
|
gptkb:Glutathione_peroxidase
|
|
gptkbp:bfsLayer
|
7
|