Statements (54)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:gene
|
| gptkbp:alternativeName |
GLUR2
GluR-K2 GluR2 |
| gptkbp:associatedWith |
epilepsy
intellectual disability neurodevelopmental disorders |
| gptkbp:biologicalProcess |
synaptic transmission
learning and memory glutamate receptor activity |
| gptkbp:discoveredBy |
researchers studying glutamate receptors
|
| gptkbp:encodes |
GluA2 protein
|
| gptkbp:Entrez_Gene_ID |
2891
ENSG00000183454 |
| gptkbp:expressedIn |
brain
central nervous system |
| gptkbp:fullName |
glutamate ionotropic receptor AMPA type subunit 2
|
| gptkbp:function |
codes for a subunit of the AMPA receptor
involved in fast excitatory synaptic transmission in the CNS |
| gptkbp:HGNC_ID |
HGNC:4584
|
| https://www.w3.org/2000/01/rdf-schema#label |
GRIA2 gene
|
| gptkbp:interactsWith |
gptkb:PSD-95
gptkb:GRIA1_gene gptkb:GRIA3_gene gptkb:GRIA4_gene stargazin TARPs (transmembrane AMPA receptor regulatory proteins) |
| gptkbp:locatedOnChromosome |
gptkb:chromosome_4
4q32.1 |
| gptkbp:mutationAssociatedWith |
gptkb:autism_spectrum_disorder
intellectual disability seizures developmental delay GRIA2-related neurodevelopmental disorder can alter calcium permeability of AMPA receptors |
| gptkbp:OMIM |
138247
|
| gptkbp:organism |
gptkb:Homo_sapiens
|
| gptkbp:orthologInMouse |
Gria2
|
| gptkbp:pathway |
glutamatergic synapse
neurotransmitter receptor binding and downstream transmission |
| gptkbp:postTranscriptionalModification |
RNA editing
|
| gptkbp:postTranslationalModification |
palmitoylation
phosphorylation ubiquitination |
| gptkbp:product |
AMPA receptor subunit GluA2
tetrameric assembly in AMPA receptors |
| gptkbp:proteinFamily |
ionotropic glutamate receptor family
|
| gptkbp:regulates |
RNA editing at Q/R site
|
| gptkbp:splicingVariant |
flip
flop |
| gptkbp:UniProtID |
P42262
|
| gptkbp:bfsParent |
gptkb:AMPA_receptors
gptkb:GluA2 |
| gptkbp:bfsLayer |
8
|