Statements (53)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:voltage-gated_potassium_channel
gptkb:protein |
| gptkbp:activatedBy |
gptkb:gamma-aminobutyric_acid
|
| gptkbp:associatedWith |
epilepsy
muscle relaxation insomnia anxiety disorders sedation |
| gptkbp:discoveredIn |
1977
|
| gptkbp:encodedBy |
gptkb:GABRA1_gene
gptkb:GABRB2_gene gptkb:GABRG2_gene |
| gptkbp:enemyOf |
gptkb:bicuculline
gptkb:picrotoxin |
| gptkbp:foundIn |
central nervous system
|
| gptkbp:function |
mediates inhibitory neurotransmission
|
| https://www.w3.org/2000/01/rdf-schema#label |
GABA-A receptor
|
| gptkbp:inhibitedBy |
gptkb:flumazenil
|
| gptkbp:locatedOnChromosome |
chromosome 4 (GABRB2)
chromosome 5 (GABRA1) chromosome 5 (GABRG2) |
| gptkbp:modulatedBy |
gptkb:benzodiazepines
ethanol barbiturates general anesthetics neurosteroids |
| gptkbp:OMIM |
137160
|
| gptkbp:PDB |
6HUO
6HUP |
| gptkbp:permeableTo |
chloride ions
|
| gptkbp:relatedTo |
gptkb:GABA-B_receptor
GABA-C receptor |
| gptkbp:structure |
pentameric
|
| gptkbp:subunit |
alpha subunit
beta subunit gamma subunit delta subunit epsilon subunit pi subunit rho subunit theta subunit |
| gptkbp:target |
general anesthetics
anticonvulsant drugs anxiolytic drugs muscle relaxants sedative drugs hypnotic drugs |
| gptkbp:UniProtID |
P14867 (alpha1 subunit)
P18507 (gamma2 subunit) P47870 (beta2 subunit) |
| gptkbp:bfsParent |
gptkb:GABRR1
gptkb:GABRR3 |
| gptkbp:bfsLayer |
7
|