|
gptkbp:instanceOf
|
gptkb:protein
gptkb:G_protein-coupled_receptor
|
|
gptkbp:activatedBy
|
G protein inwardly-rectifying potassium channels
|
|
gptkbp:associatedWith
|
addiction
epilepsy
anxiety
spasticity
|
|
gptkbp:discoveredBy
|
Norman Bowery
|
|
gptkbp:discoveredIn
|
1980
|
|
gptkbp:drugClass
|
metabotropic receptor
|
|
gptkbp:encodedBy
|
gptkb:GABBR1_gene
gptkb:GABBR2_gene
|
|
gptkbp:enemyOf
|
gptkb:baclofen
gptkb:phaclofen
gptkb:saclofen
GHB
CGP-35348
CGP-55845
SKF-97541
|
|
gptkbp:foundIn
|
central nervous system
peripheral nervous system
|
|
gptkbp:function
|
mediates inhibitory neurotransmission
|
|
gptkbp:GO_term
|
GO:0004890
|
|
gptkbp:hasClinicalUse
|
treatment of spasticity
treatment of neuropathic pain
treatment of alcohol dependence
treatment of multiple sclerosis symptoms
treatment of muscle rigidity
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
GABA-B receptor
|
|
gptkbp:inhibitedBy
|
gptkb:adenylate_cyclase
voltage-gated calcium channels
|
|
gptkbp:involvedIn
|
signal transduction
synaptic transmission
modulation of neurotransmitter release
|
|
gptkbp:ligand
|
gptkb:gamma-aminobutyric_acid
|
|
gptkbp:membraneLocation
|
postsynaptic membrane
presynaptic membrane
|
|
gptkbp:OMIM
|
603540
|
|
gptkbp:regulates
|
neurotransmitter release
neuronal excitability
|
|
gptkbp:relatedTo
|
gptkb:GABA-A_receptor
GABA-C receptor
|
|
gptkbp:structure
|
heterodimer
|
|
gptkbp:subunit
|
gptkb:GABBR1
gptkb:GABBR2
|
|
gptkbp:UniProtID
|
gptkb:O75899
gptkb:Q9UBS5
|
|
gptkbp:bfsParent
|
gptkb:GABBR1_isoforms
gptkb:GABBR2
gptkb:GABBR2_isoforms
|
|
gptkbp:bfsLayer
|
7
|