|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alternativeName
|
gptkb:PACE
Paired basic amino acid cleaving enzyme
|
|
gptkbp:associated_disease_model
|
gptkb:cancer
infectious diseases
metabolic disorders
|
|
gptkbp:biologicalProcess
|
proteolysis
protein processing
|
|
gptkbp:cellularComponent
|
gptkb:trans-Golgi_network
gptkb:Golgi_apparatus
|
|
gptkbp:encodes
|
furin protein (mouse)
|
|
gptkbp:Entrez_Gene_ID
|
18562
ENSMUSG00000021732
|
|
gptkbp:expressedIn
|
various tissues
|
|
gptkbp:function
|
serine-type endopeptidase activity
proprotein convertase activity
|
|
gptkbp:gene
|
Furin
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Furin (mouse gene)
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_7_(mouse)
|
|
gptkbp:MGI_ID
|
MGI:109563
|
|
gptkbp:mutationAssociatedWith
|
embryonic lethality
|
|
gptkbp:organism
|
gptkb:Mus_musculus
|
|
gptkbp:orthologIn
|
FURIN (human gene)
|
|
gptkbp:pathway
|
gptkb:TGF-beta_signaling_pathway
gptkb:Notch_signaling_pathway
gptkb:Wnt_signaling_pathway
|
|
gptkbp:proteinFamily
|
proprotein convertase family
P/Homo B domain
peptidase S8 domain
|
|
gptkbp:regulates
|
regulated by hypoxia
regulated by growth factors
regulated by cytokines
|
|
gptkbp:requires
|
embryonic development
|
|
gptkbp:substrate
|
gptkb:proalbumin
pro-ADAMTS
pro-BDNF
pro-IGF1R
pro-MT1-MMP
pro-PCSK9
pro-TGF-beta
pro-VEGF
|
|
gptkbp:UniProtID
|
Q61503
|
|
gptkbp:bfsParent
|
gptkb:Furin_(gene)
|
|
gptkbp:bfsLayer
|
8
|