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gptkbp:instanceOf
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gptkb:gene
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gptkbp:alternativeName
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gptkb:PACE
Paired basic amino acid cleaving enzyme
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gptkbp:associated_disease_model
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gptkb:cancer
infectious diseases
metabolic disorders
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gptkbp:biologicalProcess
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proteolysis
protein processing
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gptkbp:cellularComponent
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gptkb:trans-Golgi_network
gptkb:Golgi_apparatus
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gptkbp:encodes
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furin protein (mouse)
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gptkbp:Entrez_Gene_ID
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18562
ENSMUSG00000021732
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gptkbp:expressedIn
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various tissues
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gptkbp:function
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serine-type endopeptidase activity
proprotein convertase activity
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gptkbp:gene
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Furin
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gptkbp:locatedOnChromosome
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gptkb:chromosome_7_(mouse)
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gptkbp:MGI_ID
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MGI:109563
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gptkbp:mutationAssociatedWith
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embryonic lethality
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gptkbp:organism
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gptkb:Mus_musculus
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gptkbp:orthologIn
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FURIN (human gene)
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gptkbp:pathway
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gptkb:TGF-beta_signaling_pathway
gptkb:Notch_signaling_pathway
gptkb:Wnt_signaling_pathway
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gptkbp:proteinFamily
|
proprotein convertase family
P/Homo B domain
peptidase S8 domain
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gptkbp:regulates
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regulated by hypoxia
regulated by growth factors
regulated by cytokines
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gptkbp:requires
|
embryonic development
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gptkbp:substrate
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gptkb:proalbumin
pro-ADAMTS
pro-BDNF
pro-IGF1R
pro-MT1-MMP
pro-PCSK9
pro-TGF-beta
pro-VEGF
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gptkbp:UniProtID
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Q61503
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gptkbp:bfsParent
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gptkb:Furin_(gene)
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gptkbp:bfsLayer
|
8
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https://www.w3.org/2000/01/rdf-schema#label
|
Furin (mouse gene)
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