Fanconi anemia DNA repair pathway
GPTKB entity
Statements (33)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
biological pathway
|
| gptkbp:activatedBy |
DNA interstrand crosslinks
|
| gptkbp:associatedWith |
gptkb:Fanconi_anemia
|
| gptkbp:component |
cellular response to DNA damage
|
| gptkbp:disruptionLeadsTo |
bone marrow failure
chromosomal instability cancer predisposition |
| gptkbp:firstDescribed |
1990s
|
| gptkbp:function |
homologous recombination
interstrand crosslink repair |
| https://www.w3.org/2000/01/rdf-schema#label |
Fanconi anemia DNA repair pathway
|
| gptkbp:involvedIn |
gptkb:PALB2
gptkb:FANCA gptkb:FANCB gptkb:FANCC gptkb:FANCD2 gptkb:FANCE gptkb:FANCF gptkb:FANCG gptkb:FANCI gptkb:FANCJ gptkb:FANCL gptkb:FANCM gptkb:BRCA1 gptkb:BRCA2 gptkb:RAD51 DNA repair |
| gptkbp:regulates |
cell cycle checkpoints
|
| gptkbp:relatedTo |
BRCA pathway
|
| gptkbp:studiedIn |
mouse models
human cells |
| gptkbp:bfsParent |
gptkb:Fanconi_anemia_group_M_protein
|
| gptkbp:bfsLayer |
7
|