Statements (66)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:DNA
|
| gptkbp:associated_with |
gptkb:anemia
|
| gptkbp:code |
FANCM protein
|
| gptkbp:discovered_by |
2000s
|
| gptkbp:function |
DNA repair
|
| gptkbp:genetic_studies |
increased cancer risk
|
| gptkbp:has_role |
cell cycle regulation
|
| gptkbp:has_variants |
FANCM c.1 A> G
FANCM c.2 G> A FANCM c.3 C> T FANCM c.4 T> C |
| https://www.w3.org/2000/01/rdf-schema#label |
FANCM
|
| gptkbp:interacts_with |
gptkb:BRCA2
gptkb:BRCA1 |
| gptkbp:involved_in |
DNA crosslink repair
|
| gptkbp:is_associated_with |
gptkb:myelodysplastic_syndromes
gptkb:Oncology gptkb:neuroblastoma ovarian cancer genetic instability |
| gptkbp:is_essential_for |
genomic stability
|
| gptkbp:is_expressed_in |
various tissues
tumor microenvironment adult tissues embryonic stem cells cancerous tissues |
| gptkbp:is_involved_in |
cellular homeostasis
homologous recombination chromosomal stability tumor suppression tumorigenesis cellular differentiation cancer progression cellular signaling pathways protein-protein interactions cellular repair mechanisms cellular response to DNA damage cellular repair pathways cellular apoptosis DNA replication stress |
| gptkbp:is_linked_to |
environmental factors
DNA damage response genetic predisposition chromosomal aberrations clinical outcomes therapeutic resistance |
| gptkbp:is_part_of |
nuclear matrix
Fanconi anemia pathway DNA repair complex repair machinery DNA damage repair pathways nuclear repair complexes |
| gptkbp:is_regulated_by |
gptkb:BRCA2
gptkb:BRCA1 |
| gptkbp:is_studied_for |
gptkb:gene_therapy
drug development personalized medicine biomarker development |
| gptkbp:is_studied_in |
genetic disorders
cancer research |
| gptkbp:is_targeted_at |
small molecules
|
| gptkbp:located_in |
human chromosome 2
|
| gptkbp:orthologs |
gptkb:mouse
|
| gptkbp:promoter |
gptkb:FANCM
|
| gptkbp:bfsParent |
gptkb:anemia
|
| gptkbp:bfsLayer |
5
|