|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:alternativeName
|
gptkb:fatty_acid_synthase_complex
gptkb:FAS
|
|
gptkbp:associatedWith
|
gptkb:cancer
|
|
gptkbp:cofactor
|
gptkb:Coenzyme_A
NADPH
|
|
gptkbp:EC_number
|
2.3.1.85
|
|
gptkbp:expressedIn
|
liver
adipose tissue
mammary gland
|
|
gptkbp:firstDescribed
|
1960s
|
|
gptkbp:foundIn
|
animals
fungi
plants
|
|
gptkbp:function
|
catalyzes fatty acid synthesis
|
|
gptkbp:gene
|
gptkb:FASN
|
|
gptkbp:GO_term
|
gptkb:GO:0004312
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Fatty Acid Synthase
|
|
gptkbp:inhibitedBy
|
gptkb:C75
gptkb:cerulenin
gptkb:epigallocatechin_gallate
gptkb:orlistat
gptkb:platensimycin
gptkb:triclosan
|
|
gptkbp:location
|
gptkb:cytoplasm
|
|
gptkbp:molecularWeight
|
~540 kDa (mammals)
|
|
gptkbp:pathway
|
fatty acid biosynthesis
|
|
gptkbp:PDB
|
2JFD
2VZ8
3HHD
|
|
gptkbp:product
|
gptkb:CoA
gptkb:palmitate
CO2
NADP+
|
|
gptkbp:regulates
|
downregulated by polyunsaturated fatty acids
upregulated by insulin
upregulated in many cancers
|
|
gptkbp:relatedTo
|
lipogenesis
|
|
gptkbp:reviewedBy
|
gptkb:Annual_Review_of_Biochemistry
|
|
gptkbp:significance
|
target for anti-obesity drugs
target for anticancer drugs
|
|
gptkbp:structure
|
homodimer in mammals
multimeric in fungi
|
|
gptkbp:substrate
|
gptkb:malonyl-CoA
NADPH
acetyl-CoA
|
|
gptkbp:subunit
|
multienzyme complex
|
|
gptkbp:UniProtID
|
gptkb:P49327
|
|
gptkbp:bfsParent
|
gptkb:FAS
|
|
gptkbp:bfsLayer
|
5
|