Exchange Protein directly Activated by cAMP
GPTKB entity
Statements (44)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:abbreviation |
gptkb:EPAC
|
| gptkbp:activatedBy |
cyclic AMP
|
| gptkbp:alternativeName |
cAMP-regulated guanine nucleotide exchange factor
Rap guanine nucleotide exchange factor RapGEF |
| gptkbp:discoveredBy |
1998
|
| gptkbp:domain |
RA domain
REM domain cAMP-binding domain CDC25-HD domain |
| gptkbp:encodedBy |
RAPGEF3 gene
RAPGEF4 gene |
| gptkbp:foundIn |
humans
mammals |
| gptkbp:function |
guanine nucleotide exchange factor
|
| gptkbp:gene |
gptkb:RAPGEF3
gptkb:RAPGEF4 |
| gptkbp:hasIsoform |
gptkb:EPAC1
gptkb:EPAC2 |
| https://www.w3.org/2000/01/rdf-schema#label |
Exchange Protein directly Activated by cAMP
|
| gptkbp:involves |
immune response
cell adhesion cell junction formation insulin secretion neuronal signaling cardiac function |
| gptkbp:locale |
gptkb:nucleus
gptkb:cytoplasm gptkb:plasma_membrane |
| gptkbp:notablePublication |
de Rooij et al., Nature 1998
|
| gptkbp:regulates |
gptkb:Rap1
gptkb:Rap2 small GTPases |
| gptkbp:relatedTo |
gptkb:protein_kinase_A
|
| gptkbp:studiedBy |
cancer research
diabetes research cardiovascular research |
| gptkbp:target |
pharmacological inhibitors
pharmacological activators |
| gptkbp:UniProtID |
O95398
Q8WZA2 |
| gptkbp:bfsParent |
gptkb:Epac
|
| gptkbp:bfsLayer |
7
|