Exchange Protein directly Activated by cAMP

URI: https://gptkb.org/entity/Exchange_Protein_directly_Activated_by_cAMP
GPTKB entity
Statements (44)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:abbreviation gptkb:EPAC
gptkbp:activatedBy cyclic AMP
gptkbp:alternativeName cAMP-regulated guanine nucleotide exchange factor
Rap guanine nucleotide exchange factor
RapGEF
gptkbp:discoveredBy 1998
gptkbp:domain RA domain
REM domain
cAMP-binding domain
CDC25-HD domain
gptkbp:encodedBy RAPGEF3 gene
RAPGEF4 gene
gptkbp:foundIn humans
mammals
gptkbp:function gptkb:guanine_nucleotide_exchange_factor
gptkbp:gene gptkb:RAPGEF3
gptkb:RAPGEF4
gptkbp:hasIsoform gptkb:EPAC1
gptkb:EPAC2
gptkbp:involves gptkb:immune_response
cell adhesion
cell junction formation
insulin secretion
neuronal signaling
cardiac function
gptkbp:locale gptkb:nucleus
gptkb:cytoplasm
gptkb:plasma_membrane
gptkbp:notablePublication de Rooij et al., Nature 1998
gptkbp:regulates gptkb:Rap1
gptkb:Rap2
small GTPases
gptkbp:relatedTo gptkb:protein_kinase_A
gptkbp:studiedBy cancer research
diabetes research
cardiovascular research
gptkbp:target pharmacological inhibitors
pharmacological activators
gptkbp:UniProtID O95398
Q8WZA2
gptkbp:bfsParent gptkb:Epac
gptkbp:bfsLayer 7
https://www.w3.org/2000/01/rdf-schema#label Exchange Protein directly Activated by cAMP