|
gptkbp:instanceOf
|
gptkb:antibiotic
|
|
gptkbp:approvedBy
|
1952
|
|
gptkbp:ATCCode
|
gptkb:J01FA01
|
|
gptkbp:availableOn
|
gptkb:hospital
gptkb:tablet
capsule
suspension
injection
|
|
gptkbp:brand
|
gptkb:Erythrocin
gptkb:Ilosone
gptkb:E.E.S.
gptkb:Ery-Tab
PCE
|
|
gptkbp:CASNumber
|
114-07-8
|
|
gptkbp:contraindication
|
gptkb:liver_disease
hypersensitivity to macrolides
|
|
gptkbp:discoveredBy
|
gptkb:J._M._McGuire
|
|
gptkbp:discoveredIn
|
1952
|
|
gptkbp:drugClass
|
macrolide
|
|
gptkbp:eliminationHalfLife
|
1.5 hours
|
|
gptkbp:excretion
|
urine
bile
|
|
gptkbp:hasEnantiomer
|
gptkb:Erythromycin_A
gptkb:Erythromycin_B
gptkb:Erythromycin_C
gptkb:Erythromycin_D
|
|
gptkbp:hasMolecularFormula
|
C37H67NO13
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Erythromycin
|
|
gptkbp:interactsWith
|
gptkb:cyclosporine
gptkb:theophylline
gptkb:warfarin
gptkb:pimozide
gptkb:carbamazepine
gptkb:cisapride
gptkb:ergotamine
gptkb:digoxin
gptkb:dihydroergotamine
statins
colchicine
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:legalStatusAU
|
prescription only
|
|
gptkbp:legalStatusUK
|
prescription only
|
|
gptkbp:mechanismOfAction
|
inhibits bacterial protein synthesis
binds to 50S ribosomal subunit
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:pregnancyCategory
|
B
|
|
gptkbp:producedBy
|
gptkb:Saccharopolyspora_erythraea
|
|
gptkbp:relatedTo
|
gptkb:azithromycin
gptkb:clarithromycin
gptkb:roxithromycin
|
|
gptkbp:routeOfAdministration
|
oral
topical
intravenous
|
|
gptkbp:sideEffect
|
nausea
vomiting
diarrhea
abdominal pain
QT prolongation
liver toxicity
|
|
gptkbp:usedFor
|
gptkb:legionnaires'_disease
diphtheria
skin infections
syphilis
acne
bacterial infections
respiratory tract infections
pertussis
chlamydia infections
|
|
gptkbp:WHOModelListOfEssentialMedicines
|
yes
|
|
gptkbp:bfsParent
|
gptkb:Antibiotics
|
|
gptkbp:bfsLayer
|
4
|