Erythromycin A

URI: https://gptkb.org/entity/Erythromycin_A
GPTKB entity
Statements (50)
Predicate Object
gptkbp:instanceOf gptkb:antibiotic
gptkbp:approvedBy 1952
gptkbp:ATCCode gptkb:J01FA01
gptkbp:bioavailability variable
gptkbp:brand gptkb:Erymax
gptkb:Erythrocin
gptkb:Ilosone
Erythroped
Eryc
gptkbp:CASNumber 114-07-8
gptkbp:category gptkb:World_Health_Organization_essential_medicines
gptkbp:chemical_compound C37H67NO13
gptkbp:contraindication gptkb:liver_disease
hypersensitivity to macrolides
gptkbp:discoveredBy J.M. McGuire
gptkbp:drugInteraction gptkb:theophylline
gptkb:warfarin
statins
gptkbp:excretion urine
bile
gptkbp:halfLife 1.5–2 hours
https://www.w3.org/2000/01/rdf-schema#label Erythromycin A
gptkbp:indication gptkb:Helicobacter_pylori_infection
gptkb:legionnaires'_disease
diphtheria
skin infections
respiratory tract infections
pertussis
chlamydia infections
acne vulgaris
syphilis (in penicillin-allergic patients)
gptkbp:IUPACName (3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-4-[(2,6-dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranosyl)oxy]-14-ethyl-7,12,13-trihydroxy-3,5,7,9,11,13-hexamethyl-6-[(3,4,6-trideoxy-3-dimethylamino-β-D-xylo-hexopyranosyl)oxy]oxacyclotetradecane-2,10-dione
gptkbp:legalStatus prescription only
gptkbp:mechanismOfAction inhibits protein synthesis
gptkbp:metabolism liver
gptkbp:molecularWeight 733.93 g/mol
gptkbp:pregnancyCategory B (US)
gptkbp:producedBy gptkb:Saccharopolyspora_erythraea
gptkbp:relatedTo gptkb:azithromycin
gptkb:clarithromycin
gptkb:roxithromycin
gptkbp:routeOfAdministration oral
intravenous
gptkbp:sideEffect QT prolongation
gastrointestinal upset
gptkbp:solubility slightly soluble in water
gptkbp:target 50S ribosomal subunit
gptkbp:usedFor bacterial infections
gptkbp:bfsParent gptkb:Erythromycin
gptkbp:bfsLayer 5