Epithelial Cell Adhesion Molecule

URI: https://gptkb.org/entity/Epithelial_Cell_Adhesion_Molecule
GPTKB entity
Statements (49)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:abbreviation gptkb:EpCAM
gptkbp:alternativeName gptkb:CD326
gptkbp:associatedWith carcinomas
gptkbp:cellSurfaceMarker true
gptkbp:discoveredBy Gottfried Moldenhauer
gptkbp:discoveredIn 1979
gptkbp:domain EGF-like domain
thyroglobulin repeat
gptkbp:encodedBy gptkb:EPCAM_gene
gptkbp:Entrez_Gene_ID 4072
gptkbp:expressedIn gptkb:breast
gptkb:cancer
gptkb:skin
gptkb:prostate
gptkb:testis
liver
colon
pancreas
gptkbp:foundIn epithelial tissues
gptkbp:function cell differentiation
cell proliferation
cell signaling
cell adhesion
maintenance of epithelial integrity
gptkbp:gene gptkb:EPCAM
gptkbp:glycosylation true
gptkbp:HGNC_ID HGNC:11529
https://www.w3.org/2000/01/rdf-schema#label Epithelial Cell Adhesion Molecule
gptkbp:involvedIn metastasis
epithelial-mesenchymal transition
tumor progression
gptkbp:locale gptkb:plasma_membrane
gptkbp:locatedOnChromosome 2p21
gptkbp:molecularWeight ~40 kDa
gptkbp:mutationAssociatedWith gptkb:congenital_tufting_enteropathy
gptkbp:OMIM 185535
gptkbp:orthologInMouse Epcam
gptkbp:structure single-pass type I membrane protein
gptkbp:target immunotherapy
catumaxomab
edrecolomab
gptkbp:UniProtID P16422
gptkbp:usedAs diagnostic marker
therapeutic target
cancer stem cell marker
gptkbp:bfsParent gptkb:CD326
gptkb:EpCAM
gptkbp:bfsLayer 7