|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alternativeName
|
gptkb:MECOM
MDS1 and EVI1 complex locus protein EVI1
|
|
gptkbp:associatedWith
|
gptkb:acute_myeloid_leukemia
myelodysplastic syndrome
|
|
gptkbp:contains
|
zinc finger domain
|
|
gptkbp:discoveredIn
|
1988
|
|
gptkbp:encodes
|
EVI1 protein
|
|
gptkbp:Entrez_Gene_ID
|
2122
ENSG00000115705
|
|
gptkbp:expressedIn
|
bone marrow
hematopoietic stem cells
|
|
gptkbp:fullName
|
Ecotropic Viral Integration Site 1
|
|
gptkbp:function
|
transcription factor
DNA-binding transcription factor activity
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:GOProcess
|
regulation of transcription, DNA-templated
positive regulation of cell proliferation
negative regulation of apoptotic process
|
|
gptkbp:HGNC_ID
|
HGNC:3497
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
EVI1
|
|
gptkbp:interactsWith
|
gptkb:SMAD3
gptkb:GATA2
gptkb:RUNX1
CtBP1
|
|
gptkbp:length
|
1051 amino acids
|
|
gptkbp:locatedOnChromosome
|
3
3q26.2
|
|
gptkbp:molecularWeight
|
120 kDa
|
|
gptkbp:mutationAssociatedWith
|
oncogenic transformation
|
|
gptkbp:OMIM
|
601432
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
Evi1
|
|
gptkbp:orthologInZebrafish
|
evi1a
evi1b
|
|
gptkbp:overexpressionEffect
|
poor prognosis in leukemia
|
|
gptkbp:regulates
|
apoptosis
cell proliferation
differentiation
cell cycle
hematopoiesis
TGF-beta signaling
|
|
gptkbp:relatedTo
|
chromosomal translocation t(3;3)(q21;q26)
inv(3)(q21q26)
|
|
gptkbp:splicingVariant
|
MDS1-EVI1 fusion protein
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
|
|
gptkbp:transcriptionalActivator
|
yes
|
|
gptkbp:transcriptionalRepressor
|
yes
|
|
gptkbp:UniProtID
|
Q03112
|
|
gptkbp:bfsParent
|
gptkb:chromosome_3
|
|
gptkbp:bfsLayer
|
6
|