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gptkbp:instanceOf
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gptkb:gene
|
|
gptkbp:alias
|
Extra Spindle Poles Like 1
Separin
|
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gptkbp:associatedWith
|
gptkb:cancer
aneuploidy
|
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gptkbp:biologicalProcess
|
chromosome segregation
cysteine-type endopeptidase activity
mitotic anaphase
|
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gptkbp:encodes
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gptkb:separase
|
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gptkbp:Entrez_Gene_ID
|
9700
ENSG00000155876
|
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gptkbp:expressedIn
|
various tissues
|
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gptkbp:function
|
cell cycle progression
regulation of sister chromatid separation
|
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gptkbp:geneType
|
protein-coding
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
ESPL1 gene
|
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gptkbp:interactsWith
|
gptkb:securin
gptkb:PDS5A
SGO1
|
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gptkbp:length
|
~2,133 amino acids (protein product)
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_12
12q13.13
|
|
gptkbp:mutationAssociatedWith
|
chromosomal instability
|
|
gptkbp:OMIM
|
606048
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
Espl1
|
|
gptkbp:pathway
|
mitosis
cell cycle
|
|
gptkbp:product
|
gptkb:separase
|
|
gptkbp:regulates
|
activated by APC/C
inhibited by securin
cohesin complex cleavage
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:UniProtID
|
Q14674
|
|
gptkbp:bfsParent
|
gptkb:Separase
|
|
gptkbp:bfsLayer
|
7
|