ABCG2 gene
E856800
The ABCG2 gene encodes a membrane transporter protein involved in multidrug resistance and the efflux of various xenobiotics and endogenous compounds across cellular membranes.
All labels observed (4)
| Label | Occurrences |
|---|---|
| ABCG2 | 1 |
| ABCG2 gene canonical | 1 |
| ABCG2 protein | 1 |
| ATP-binding cassette sub-family G member 2 | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T10291855 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: ABCG2 gene Context triple: [BCRP, encodedBy, ABCG2 gene]
-
A.
P-glycoprotein
P-glycoprotein is a membrane-bound efflux transporter protein that pumps various drugs and xenobiotics out of cells, influencing their absorption, distribution, and resistance profiles.
-
B.
CYP2D6
CYP2D6 is a highly polymorphic cytochrome P450 enzyme that plays a major role in the metabolism of many drugs, contributing significantly to interindividual variability in drug response.
-
C.
CYP3A4
CYP3A4 is a major human liver and intestinal enzyme of the cytochrome P450 family responsible for metabolizing a wide range of drugs and xenobiotics.
-
D.
CYP1A2
CYP1A2 is a liver enzyme of the cytochrome P450 family that plays a key role in the metabolism of various drugs and xenobiotics.
-
E.
CYP2C19
CYP2C19 is a liver enzyme of the cytochrome P450 family that plays a key role in the metabolism of various drugs, including certain antidepressants, proton pump inhibitors, and antiplatelet agents.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: ABCG2 gene Target entity description: The ABCG2 gene encodes a membrane transporter protein involved in multidrug resistance and the efflux of various xenobiotics and endogenous compounds across cellular membranes.
-
A.
P-glycoprotein
P-glycoprotein is a membrane-bound efflux transporter protein that pumps various drugs and xenobiotics out of cells, influencing their absorption, distribution, and resistance profiles.
-
B.
CYP2D6
CYP2D6 is a highly polymorphic cytochrome P450 enzyme that plays a major role in the metabolism of many drugs, contributing significantly to interindividual variability in drug response.
-
C.
CYP3A4
CYP3A4 is a major human liver and intestinal enzyme of the cytochrome P450 family responsible for metabolizing a wide range of drugs and xenobiotics.
-
D.
CYP1A2
CYP1A2 is a liver enzyme of the cytochrome P450 family that plays a key role in the metabolism of various drugs and xenobiotics.
-
E.
CYP2C19
CYP2C19 is a liver enzyme of the cytochrome P450 family that plays a key role in the metabolism of various drugs, including certain antidepressants, proton pump inhibitors, and antiplatelet agents.
- F. None of above. chosen
Statements (52)
| Predicate | Object |
|---|---|
| instanceOf | gene ⓘ |
| associatedWith |
clinical multidrug resistance in cancer
ⓘ
gout ⓘ hyperuricemia ⓘ pharmacokinetics of many drugs ⓘ |
| belongsToFamily | ATP-binding cassette transporter family ⓘ |
| belongsToSubfamily |
ABC subfamily G
ⓘ
linked to:
ATP-binding cassette transporter family
|
| encodes |
ABCG2 protein
ⓘ
linked to:
ABCG2 gene
ATP-binding cassette sub-family G member 2 ⓘ
linked to:
ABCG2 gene
BCRP ⓘ MXR ⓘ breast cancer resistance protein ⓘ
linked to:
BCRP
mitoxantrone resistance protein ⓘ
linked to:
MRP1 (ABCC1)
|
| hasBiologicalProcess |
heme transport
ⓘ
multidrug resistance ⓘ porphyrin transport ⓘ protection of stem cells from xenobiotics ⓘ uric acid transport ⓘ xenobiotic efflux ⓘ |
| hasCellularComponent |
apical plasma membrane
ⓘ
plasma membrane ⓘ |
| hasMolecularFunction |
ATP-dependent transmembrane transporter activity
ⓘ
drug transmembrane transporter activity ⓘ xenobiotic-transporting ATPase activity ⓘ |
| hasPolymorphism | Q141K variant ⓘ |
| HGNCID | HGNC:73 ⓘ |
| highlyExpressedIn |
blood-brain barrier endothelial cells
ⓘ
hematopoietic stem cells ⓘ intestine ⓘ kidney ⓘ liver ⓘ placenta ⓘ |
| locatedOnChromosome | human chromosome 4q22 ⓘ |
| NCBIGeneID | 9429 ⓘ |
| playsRoleIn |
maternal-fetal xenobiotic barrier in placenta
ⓘ
protection of blood-brain barrier from xenobiotics ⓘ |
| Q141KVariantAssociatedWith |
altered drug disposition
ⓘ
increased risk of gout ⓘ reduced transporter activity ⓘ |
| regulatedBy |
estrogen receptor signaling
ⓘ
hypoxia-inducible factors ⓘ nuclear receptors PXR and CAR ⓘ
linked to:
constitutive androstane receptor
|
| transportSubstrate |
anticancer drugs
ⓘ
fluoroquinolone antibiotics ⓘ glucuronide conjugates ⓘ methotrexate ⓘ mitoxantrone ⓘ statins ⓘ sulfate conjugates ⓘ topotecan ⓘ uric acid ⓘ |
| uniprotID | Q9UNQ0 ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: ABCG2 gene Description of subject: The ABCG2 gene encodes a membrane transporter protein involved in multidrug resistance and the efflux of various xenobiotics and endogenous compounds across cellular membranes.
Referenced by (4)
Full triples — surface form annotated when it differs from this entity's canonical label.