PDZ domain-containing proteins
GPTKB entity
Statements (54)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:abbreviation |
PSD-95/Dlg/ZO-1 domain-containing proteins
|
| gptkbp:associatedWith |
gptkb:cancer
neurological disorders cystic fibrosis |
| gptkbp:binds |
C-terminal motifs of target proteins
|
| gptkbp:database |
InterPro: IPR001478
PROSITE: PS50106 Pfam: PF00595 SCOP: 1bfe |
| gptkbp:domain |
PDZ domain
|
| gptkbp:example |
gptkb:NHERF1
gptkb:PSD-95 gptkb:DLG1 gptkb:SAP97 GRIP1 ZO-1 Discs large homolog LIN-2 MUPP1 Shank proteins Syntenin |
| gptkbp:first_identified_in |
1992
|
| gptkbp:foundIn |
eukaryotes
|
| gptkbp:function |
protein-protein interaction
|
| gptkbp:GO_term |
GO:0019902
|
| https://www.w3.org/2000/01/rdf-schema#label |
PDZ domain-containing proteins
|
| gptkbp:interactsWith |
ion channels
G-protein coupled receptors cytoskeletal proteins signaling molecules |
| gptkbp:involves |
signal transduction
neural development cell junction assembly membrane protein localization |
| gptkbp:locale |
gptkb:plasma_membrane
synapse tight junctions adherens junctions |
| gptkbp:namedAfter |
gptkb:PSD-95
gptkb:DLG1 ZO-1 |
| gptkbp:number_of_amino_acids_in_domain |
80-90
|
| gptkbp:role |
cell signaling
synaptic transmission scaffolding cell polarity receptor clustering |
| gptkbp:structure |
modular
|
| gptkbp:bfsParent |
gptkb:E6_protein_of_HPV
gptkb:Neuroglycan_C gptkb:FAP-1 gptkb:Tyrosine-protein_phosphatase_non-receptor_type_13 |
| gptkbp:bfsLayer |
8
|