Dual specificity tyrosine-phosphorylation-regulated kinase 1A

URI: https://gptkb.org/entity/Dual_specificity_tyrosine-phosphorylation-regulated_kinase_1A
GPTKB entity
Statements (41)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkb:enzyme
gptkbp:abbreviation gptkb:DYRK1A
gptkbp:alternativeName DYRK1A protein
Minibrain kinase
gptkbp:discoveredBy James F. Battey Jr.
gptkbp:discoveredIn 1995
gptkbp:encodedBy DYRK1A gene
gptkbp:Entrez_Gene_ID 1859
gptkbp:enzymeClassification gptkb:EC_2.7.12.1
gptkbp:function protein kinase activity
phosphorylation of serine/threonine and tyrosine residues
https://www.w3.org/2000/01/rdf-schema#label Dual specificity tyrosine-phosphorylation-regulated kinase 1A
gptkbp:inhibitedBy gptkb:epigallocatechin_gallate
gptkb:harmine
gptkbp:involvedIn cell cycle regulation
neuronal development
transcription regulation
gptkbp:locatedOnChromosome chromosome 21q22.13
gptkbp:location gptkb:nucleus
gptkb:cytoplasm
gptkbp:molecularWeight ~85 kDa
gptkbp:mutationAssociatedWith gptkb:autism_spectrum_disorder
intellectual disability
microcephaly
gptkbp:OMIM 600855
gptkbp:organism gptkb:Homo_sapiens
gptkbp:orthologIn gptkb:Mus_musculus
gptkb:Drosophila_melanogaster
gptkbp:PDB 4YU2
gptkbp:phosphorylates gptkb:cyclin_D1
gptkb:tau_protein
gptkb:histone_H3
gptkbp:relatedTo gptkb:Alzheimer's_disease
gptkb:Down_syndrome
neurodevelopment
gptkbp:structure contains protein kinase domain
contains nuclear localization signal
gptkbp:UniProtID Q13627
gptkbp:bfsParent gptkb:DYRK1A
gptkbp:bfsLayer 7