|
gptkbp:instanceOf
|
gptkb:protein
gptkb:G_protein-coupled_receptor
|
|
gptkbp:alternativeName
|
gptkb:dopamine_receptor_D3
gptkb:D3R
gptkb:DRD3
|
|
gptkbp:associatedWith
|
gptkb:Parkinson's_disease
addiction
schizophrenia
|
|
gptkbp:binds
|
antagonists
dopamine
agonists
|
|
gptkbp:couplingType
|
gptkb:Gi/o_proteins
|
|
gptkbp:encodedBy
|
gptkb:DRD3_gene
|
|
gptkbp:Entrez_Gene_ID
|
1814
|
|
gptkbp:expressedIn
|
gptkb:nucleus_accumbens
gptkb:ventral_striatum
gptkb:olfactory_tubercle
cerebellum (low levels)
cerebral cortex (low levels)
hippocampus (low levels)
islands of Calleja
thalamus (low levels)
|
|
gptkbp:foundIn
|
gptkb:human
mammals
|
|
gptkbp:HGNC_ID
|
gptkb:HGNC:3025
|
|
gptkbp:highExpressionIn
|
limbic areas
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
dopamine D3 receptor
|
|
gptkbp:involvedIn
|
cognition
emotion
reward pathways
modulation of neurotransmission
|
|
gptkbp:locatedIn
|
central nervous system
|
|
gptkbp:locatedOnChromosome
|
3q13.31
|
|
gptkbp:memberOf
|
gptkb:dopamine_receptor_family
|
|
gptkbp:orthologIn
|
gptkb:dog
gptkb:lion
gptkb:livestock
gptkb:mouse
right
|
|
gptkbp:structure
|
seven transmembrane domains
|
|
gptkbp:target
|
gptkb:cariprazine
antipsychotic drugs
antagonists
partial agonists
pramipexole
ropinirole
|
|
gptkbp:type
|
inhibits adenylyl cyclase
|
|
gptkbp:UniProtID
|
gptkb:P35462
|
|
gptkbp:bfsParent
|
gptkb:D3RC
gptkb:dopamine_receptor_D3
|
|
gptkbp:bfsLayer
|
7
|