DB01257

GPTKB entity

Statements (54)
Predicate Object
gptkbp:instanceOf gptkb:drug
gptkbp:approvalYear 2004
gptkbp:ATCCode gptkb:N06AX21
gptkbp:bioavailability 50%
gptkbp:brand gptkb:Cymbalta
Irenka
gptkbp:CASNumber gptkb:136434-34-9
gptkbp:contraindication concurrent use with MAO inhibitors
uncontrolled narrow-angle glaucoma
gptkbp:drugClass antidepressant
norepinephrine reuptake inhibitor
gptkbp:eliminationHalfLife 12 hours
gptkbp:hasInChIKey MRXVRMABMABQOQ-UHFFFAOYSA-N
gptkbp:hasMolecularFormula gptkb:C18H19NOS
gptkbp:hasPatentExpiry 2013 (US)
gptkbp:hasSMILES CN(C)CCOC1=CC=CC=C1C2=CC=CS2
gptkbp:hasUNII O5TNM5N07U
https://www.w3.org/2000/01/rdf-schema#label DB01257
gptkbp:indication gptkb:generalized_anxiety_disorder
gptkb:major_depressive_disorder
fibromyalgia
chronic musculoskeletal pain
diabetic peripheral neuropathic pain
gptkbp:legalStatus prescription only
gptkbp:manufacturer gptkb:Eli_Lilly_and_Company
gptkbp:mechanismOfAction inhibits reuptake of serotonin and norepinephrine
gptkbp:metabolism liver
gptkbp:molecularWeight 297.42
gptkbp:name gptkb:Duloxetine
gptkbp:pregnancyCategory C (US)
gptkbp:proteinBinding 96%
gptkbp:PubChem_CID gptkb:DB01257
60835
CHEBI:36794
D07861
gptkbp:routeOfAdministration oral
gptkbp:sideEffect nausea
constipation
dry mouth
somnolence
decreased appetite
gptkbp:target gptkb:SLC6A4
gptkb:SLC6A2
gptkb:HTR1B
gptkb:OPRD1
gptkb:OPRK1
gptkb:OPRM1
HTR2A
CHRNA7
HTR1A
HTR2C
HTR7
gptkbp:bfsParent gptkb:Soliris
gptkbp:bfsLayer 7