gptkbp:instanceOf
|
gptkb:drug
|
gptkbp:approvalYear
|
2006
|
gptkbp:approvedBy
|
gptkb:FDA
gptkb:EMA
|
gptkbp:ATCCode
|
gptkb:L01XE04
|
gptkbp:availableOn
|
capsule
|
gptkbp:bioavailability
|
50%
|
gptkbp:brand
|
gptkb:Sutent
|
gptkbp:CASNumber
|
gptkb:557795-19-4
|
gptkbp:color
|
gptkb:orange
caramel
|
gptkbp:contraindication
|
pregnancy
|
gptkbp:halfLife
|
40-60 hours
|
gptkbp:hasDrugBankURL
|
https://go.drugbank.com/drugs/DB01234
|
gptkbp:hasInChIKey
|
UZTWTKQGDNQDFZ-UHFFFAOYSA-N
|
gptkbp:hasMolecularFormula
|
C22H27FN4O2
|
gptkbp:hasSMILES
|
CC1=C(C=C2C(=C1)N(C(=O)N2)CC3CCCCC3)NC4=CC(=C(C=C4)F)C(=O)NC
|
gptkbp:hasUNII
|
90Y1I9G6X9
|
https://www.w3.org/2000/01/rdf-schema#label
|
DB01234
|
gptkbp:indication
|
treatment of renal cell carcinoma
treatment of gastrointestinal stromal tumor
treatment of pancreatic neuroendocrine tumors
|
gptkbp:isApprovedDrug
|
true
|
gptkbp:legalStatus
|
prescription only
patented
|
gptkbp:manufacturer
|
gptkb:Pfizer
|
gptkbp:mechanismOfAction
|
gptkb:receptor_tyrosine_kinase
|
gptkbp:metabolism
|
gptkb:CYP3A4
|
gptkbp:molecularWeight
|
398.477
|
gptkbp:name
|
gptkb:Sunitinib
|
gptkbp:pregnancyCategory
|
D (US)
|
gptkbp:PubChem_CID
|
5329102
|
gptkbp:routeOfAdministration
|
oral
|
gptkbp:sideEffect
|
gptkb:hand-foot_syndrome
diarrhea
fatigue
hypertension
neutropenia
|
gptkbp:status
|
true
|
gptkbp:target
|
gptkb:PDGFR
gptkb:VEGFR
gptkb:KIT
gptkb:FLT3
gptkb:RET
|
gptkbp:bfsParent
|
gptkb:50-02-2
|
gptkbp:bfsLayer
|
6
|