DB01126

GPTKB entity

Statements (52)
Predicate Object
gptkbp:instanceOf gptkb:drug
gptkbp:approvalYear 1994
gptkbp:ATCCode A10BA02
gptkbp:bioavailability 50-60%
gptkbp:brand gptkb:Riomet
gptkb:Fortamet
gptkb:Glucophage
gptkb:Glumetza
gptkbp:CASNumber 657-24-9
gptkbp:contraindication metabolic acidosis
renal impairment
acute or chronic metabolic acidosis
gptkbp:drugClass biguanide
gptkbp:excretion renal
gptkbp:halfLife 4-8.7 hours
gptkbp:hasGenericAvailability yes
gptkbp:hasInChIKey gptkb:XZWYZXLIPXDOLR-UHFFFAOYSA-N
gptkbp:hasMolecularFormula C4H11N5
gptkbp:hasPharmacodynamics reduces blood glucose without causing hypoglycemia
gptkbp:hasSMILES CN(C)C(=N)N=C(N)N
gptkbp:hasUNII 9100L32L2N
https://www.w3.org/2000/01/rdf-schema#label DB01126
gptkbp:indication gptkb:type_2_diabetes_mellitus
gptkbp:legalStatus prescription only
off-patent
gptkbp:manufacturer gptkb:Bristol-Myers_Squibb
gptkbp:mechanismOfAction improves insulin sensitivity
decreases hepatic glucose production
decreases intestinal absorption of glucose
gptkbp:metabolism not metabolized
gptkbp:molecularWeight 129.164
gptkbp:name gptkb:Metformin
gptkbp:pregnancyCategory B (US)
gptkbp:proteinBinding negligible
gptkbp:PubChem_CID gptkb:DB01126
gptkb:CHEMBL1431
gptkb:D01841
4091
gptkbp:routeOfAdministration oral
gptkbp:sideEffect nausea
diarrhea
gastrointestinal upset
lactic acidosis
gptkbp:synonym gptkb:Glucophage
gptkb:Metformina
gptkb:Metformine
N,N-dimethylbiguanide
gptkbp:target gptkb:AMP-activated_protein_kinase
gptkb:mitochondrial_respiratory_chain_complex_I
gptkbp:therapeuticArea endocrinology
gptkbp:bfsParent gptkb:dutasteride
gptkbp:bfsLayer 7