|
gptkbp:instanceOf
|
gptkb:drug
biguanide
|
|
gptkbp:approvalYear
|
1957
|
|
gptkbp:approvedBy
|
gptkb:France
gptkb:FDA
|
|
gptkbp:ATCCode
|
A10BA02
|
|
gptkbp:bioavailability
|
50–60%
|
|
gptkbp:brand
|
gptkb:Riomet
gptkb:Fortamet
gptkb:Glucophage
gptkb:Glumetza
|
|
gptkbp:CASNumber
|
657-24-9
|
|
gptkbp:category
|
gptkb:WHO_essential_medicine
antidiabetic medication
oral hypoglycemic agent
|
|
gptkbp:chemicalFormula
|
C4H11N5
|
|
gptkbp:compatibleWith
|
type 1 diabetes
|
|
gptkbp:contraindication
|
gptkb:liver_disease
alcoholism
renal impairment
|
|
gptkbp:discoveredBy
|
gptkb:Jean_Sterne
|
|
gptkbp:discoveredIn
|
1957
|
|
gptkbp:eliminationHalfLife
|
4-8.7 hours
|
|
gptkbp:excretion
|
gptkb:kidney
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Metformine
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:mechanismOfAction
|
decreases hepatic glucose production
increases insulin sensitivity
decreases intestinal absorption of glucose
|
|
gptkbp:MeSH_ID
|
D008687
|
|
gptkbp:metabolism
|
not metabolized
|
|
gptkbp:molecularWeight
|
129.164 g/mol
|
|
gptkbp:origin
|
derived from Galega officinalis (French lilac)
|
|
gptkbp:pregnancyCategory
|
B (US)
B3 (Australia)
|
|
gptkbp:proteinBinding
|
negligible
|
|
gptkbp:PubChem_CID
|
4091
|
|
gptkbp:riskFactor
|
lactic acidosis
|
|
gptkbp:routeOfAdministration
|
oral
|
|
gptkbp:sideEffect
|
nausea
diarrhea
abdominal pain
gastrointestinal upset
lactic acidosis
|
|
gptkbp:synonym
|
1,1-dimethylbiguanide
|
|
gptkbp:UNII
|
9100L32L2N
|
|
gptkbp:usedFor
|
gptkb:polycystic_ovary_syndrome
gptkb:type_2_diabetes
|
|
gptkbp:WHOModelListOfEssentialMedicines
|
true
|
|
gptkbp:bfsParent
|
gptkb:DB00740
gptkb:DB00783
gptkb:DB00170
|
|
gptkbp:bfsLayer
|
6
|