DB00843

GPTKB entity

Statements (56)
Predicate Object
gptkbp:instanceOf gptkb:drug
gptkbp:affiliatedWith biguanide
gptkbp:approvalYear 1994
gptkbp:approvedBy gptkb:FDA
gptkbp:ATCCode A10BA02
gptkbp:bioavailability 50-60%
gptkbp:CASNumber 657-24-9
gptkbp:color white
gptkbp:contraindication renal impairment
hepatic impairment
acute or chronic metabolic acidosis
gptkbp:discoveredBy gptkb:Jean_Sterne
gptkbp:eliminationHalfLife 4-8.7 hours
gptkbp:excretion renal
gptkbp:flavor bitter
gptkbp:hasDosageForm gptkb:tablet
oral solution
gptkbp:hasMolecularFormula C4H11N5
gptkbp:hasUNII 9100L32L2N
https://www.w3.org/2000/01/rdf-schema#label DB00843
gptkbp:indication gptkb:polycystic_ovary_syndrome
gptkb:type_2_diabetes_mellitus
gptkbp:isApprovedDrug gptkb:WHO_Model_List_of_Essential_Medicines
gptkbp:isGeneric true
gptkbp:legalStatus expired
prescription only
gptkbp:mechanismOfAction decreases hepatic glucose production
increases insulin sensitivity
decreases intestinal absorption of glucose
gptkbp:meltingPoint 223-226°C
gptkbp:metabolism not metabolized
gptkbp:molecularWeight 129.164 g/mol
gptkbp:name gptkb:Metformin
gptkbp:pregnancyCategory B (US)
gptkbp:proteinBinding negligible
gptkbp:PubChem_CID gptkb:DB00843
6801
4091
3944
D01839
gptkbp:routeOfAdministration oral
gptkbp:sideEffect nausea
diarrhea
abdominal pain
gastrointestinal upset
lactic acidosis
gptkbp:synonym gptkb:Riomet
gptkb:Fortamet
gptkb:Glucophage
gptkb:Glumetza
gptkbp:target gptkb:AMP-activated_protein_kinase
gptkb:mitochondrial_respiratory_chain_complex_I
gptkbp:usedFor gptkb:polycystic_ovary_syndrome
gptkb:type_2_diabetes_mellitus
gptkbp:bfsParent gptkb:donepezil
gptkbp:bfsLayer 8