|
gptkbp:instanceOf
|
gptkb:drug
|
|
gptkbp:approvalYear
|
1994
|
|
gptkbp:ATCCode
|
A10BA02
|
|
gptkbp:bioavailability
|
50-60%
|
|
gptkbp:brand
|
gptkb:Riomet
gptkb:Fortamet
gptkb:Glucophage
gptkb:Glumetza
|
|
gptkbp:CASNumber
|
657-24-9
|
|
gptkbp:color
|
white
|
|
gptkbp:contraindication
|
renal impairment
hepatic impairment
acute or chronic metabolic acidosis
|
|
gptkbp:drugClass
|
antidiabetic agent
biguanide
|
|
gptkbp:excretion
|
renal
|
|
gptkbp:form
|
gptkb:government_agency
gptkb:tablet
|
|
gptkbp:genericAvailable
|
true
|
|
gptkbp:halfLife
|
4-8.7 hours
|
|
gptkbp:hasInChIKey
|
gptkb:XZWYZXLIPXDOLR-UHFFFAOYSA-N
|
|
gptkbp:hasMolecularFormula
|
C4H11N5
|
|
gptkbp:hasPharmacodynamics
|
improves glycemic control
|
|
gptkbp:hasSMILES
|
CN(C)C(=N)N=C(N)N
|
|
gptkbp:hasUNII
|
9100L32L2N
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
DB00829
|
|
gptkbp:indication
|
gptkb:polycystic_ovary_syndrome
gptkb:type_2_diabetes_mellitus
|
|
gptkbp:isApprovedDrug
|
true
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:mechanismOfAction
|
decreases hepatic glucose production
increases insulin sensitivity
|
|
gptkbp:metabolism
|
not metabolized
|
|
gptkbp:molecularWeight
|
129.164
|
|
gptkbp:name
|
gptkb:Metformin
|
|
gptkbp:pregnancyCategory
|
B (US)
|
|
gptkbp:PubChem_CID
|
gptkb:DB00829
gptkb:D01841
6801
4091
|
|
gptkbp:routeOfAdministration
|
oral
|
|
gptkbp:sideEffect
|
nausea
diarrhea
gastrointestinal upset
lactic acidosis
|
|
gptkbp:synonym
|
gptkb:Glucophage
gptkb:Metformina
Metformin hydrochloride
|
|
gptkbp:target
|
gptkb:AMP-activated_protein_kinase
gptkb:mitochondrial_respiratory_chain_complex_I
|
|
gptkbp:bfsParent
|
gptkb:diazepam
|
|
gptkbp:bfsLayer
|
6
|