|
gptkbp:instanceOf
|
gptkb:drug
|
|
gptkbp:approvalYear
|
1899
|
|
gptkbp:ATCCode
|
gptkb:N02BA01
B01AC06
|
|
gptkbp:bioavailability
|
80-100%
|
|
gptkbp:boilingPoint
|
140°C (decomposes)
|
|
gptkbp:CASNumber
|
50-78-2
|
|
gptkbp:category
|
gptkb:NSAID
analgesic
Antipyretic
Antiplatelet
|
|
gptkbp:color
|
white
|
|
gptkbp:contraindication
|
asthma
peptic ulcer
children with viral infections
bleeding disorders
|
|
gptkbp:drugClass
|
gptkb:Antiplatelet_agent
nonsteroidal anti-inflammatory drug
|
|
gptkbp:eliminationHalfLife
|
2-3 hours
|
|
gptkbp:hasDrugBankURL
|
https://go.drugbank.com/drugs/DB00169
|
|
gptkbp:hasInChIKey
|
BSYNRYMUTXBXSQ-UHFFFAOYSA-N
|
|
gptkbp:hasMolecularFormula
|
C9H8O4
|
|
gptkbp:hasSMILES
|
CC(=O)Oc1ccccc1C(=O)O
|
|
gptkbp:hasUNII
|
R16CO5Y76E
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
DB00169
|
|
gptkbp:includesState
|
gptkb:stone
|
|
gptkbp:indication
|
fever
pain
inflammation
prevention of cardiovascular events
|
|
gptkbp:legalStatus
|
gptkb:OTC
expired
|
|
gptkbp:manufacturer
|
gptkb:Bayer
|
|
gptkbp:mechanismOfAction
|
irreversible inhibition of cyclooxygenase (COX-1 and COX-2)
|
|
gptkbp:meltingPoint
|
135°C
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:molecularWeight
|
180.16
|
|
gptkbp:name
|
gptkb:Aspirin
|
|
gptkbp:pregnancyCategory
|
C (first and second trimester)
D (third trimester)
|
|
gptkbp:proteinBinding
|
80-90%
|
|
gptkbp:PubChem_CID
|
2244
D00109
15365
|
|
gptkbp:routeOfAdministration
|
oral
intravenous
rectal
|
|
gptkbp:sideEffect
|
bleeding
allergic reaction
gastrointestinal ulcer
|
|
gptkbp:solubility
|
slightly soluble in water
soluble in ethanol
|
|
gptkbp:synonym
|
gptkb:ASA
gptkb:Acetylsalicylic_acid
|
|
gptkbp:target
|
gptkb:PTGS2
gptkb:Prostaglandin_G/H_synthase_2
gptkb:PTGS1
Prostaglandin G/H synthase 1
|
|
gptkbp:bfsParent
|
gptkb:cholecalciferol
|
|
gptkbp:bfsLayer
|
5
|