Cys-loop ligand-gated ion channel family
GPTKB entity
Statements (26)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:alsoKnownAs |
gptkb:Cys-loop_receptor_family
|
| gptkbp:contains |
gptkb:GABA_A_receptor
gptkb:glycine_receptor gptkb:serotonin_5-HT3_receptor gptkb:zinc-activated_ion_channel nicotinic acetylcholine receptor |
| gptkbp:evolvesFrom |
eukaryotes
|
| gptkbp:foundIn |
animals
|
| gptkbp:function |
mediate fast synaptic transmission
|
| https://www.w3.org/2000/01/rdf-schema#label |
Cys-loop ligand-gated ion channel family
|
| gptkbp:InterPro |
gptkb:IPR006202
|
| gptkbp:involvedIn |
neurotransmission
|
| gptkbp:location |
gptkb:cell_membrane
|
| gptkbp:mechanismOfAction |
ligand binding opens ion channel
|
| gptkbp:OMIM |
601199
|
| gptkbp:permeableTo |
selective for cations or anions
|
| gptkbp:proteinFamily |
gptkb:PF02932
gptkb:LGIC_family |
| gptkbp:structure |
Cys-loop (disulfide bond between two cysteines separated by 13 amino acids)
|
| gptkbp:subunit |
pentameric
|
| gptkbp:target |
drugs
neurotoxins anesthetics |
| gptkbp:bfsParent |
gptkb:Cys-loop_receptor_family
|
| gptkbp:bfsLayer |
6
|