Corticotropin-releasing hormone receptor 1

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein gptkb:G_protein-coupled_receptor
gptkbp:alternativeSplicing	yes
gptkbp:associatedWith	gptkb:depression anxiety disorders irritable bowel syndrome
gptkbp:biologicalProcess	hormone receptor activity
gptkbp:cellularComponent	gptkb:plasma_membrane
gptkbp:Entrez_Gene_ID	ENSG00000145425
gptkbp:expressedIn	gptkb:pituitary_gland brain
gptkbp:family	secretin receptor family
gptkbp:foundIn	gptkb:Homo_sapiens
gptkbp:function	mediates stress response regulates ACTH secretion
gptkbp:gene	gptkb:CRHR1
gptkbp:HGNC_ID	2357
gptkbp:length	444
gptkbp:ligand	gptkb:corticotropin-releasing_hormone gptkb:urocortin
gptkbp:locatedOnChromosome	17q21.31
gptkbp:OMIM	122561
gptkbp:orthologInMouse	gptkb:Crhr1
gptkbp:pharmacological_target	antagonists under investigation for anxiety antagonists under investigation for depression
gptkbp:RefSeq	NM_004382
gptkbp:signal_transduction_pathway	gptkb:cAMP_pathway
gptkbp:transmembraneDomains	7
gptkbp:UniProtID	gptkb:P34998
gptkbp:bfsParent	gptkb:CRHR1 gptkb:CRHR1_protein
gptkbp:bfsLayer	8
https://www.w3.org/2000/01/rdf-schema#label	Corticotropin-releasing hormone receptor 1