Corticotropin-releasing hormone receptor 1

URI: https://gptkb.org/entity/Corticotropin-releasing_hormone_receptor_1
GPTKB entity
Statements (33)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkb:G_protein-coupled_receptor
gptkbp:alternativeSplicing yes
gptkbp:associatedWith gptkb:depression
anxiety disorders
irritable bowel syndrome
gptkbp:biologicalProcess hormone receptor activity
gptkbp:cellularComponent gptkb:plasma_membrane
gptkbp:Entrez_Gene_ID ENSG00000145425
gptkbp:expressedIn gptkb:pituitary_gland
brain
gptkbp:family secretin receptor family
gptkbp:foundIn gptkb:Homo_sapiens
gptkbp:function mediates stress response
regulates ACTH secretion
gptkbp:gene gptkb:CRHR1
gptkbp:HGNC_ID 2357
https://www.w3.org/2000/01/rdf-schema#label Corticotropin-releasing hormone receptor 1
gptkbp:length 444
gptkbp:ligand gptkb:corticotropin-releasing_hormone
gptkb:urocortin
gptkbp:locatedOnChromosome 17q21.31
gptkbp:OMIM 122561
gptkbp:orthologInMouse gptkb:Crhr1
gptkbp:pharmacological_target antagonists under investigation for anxiety
antagonists under investigation for depression
gptkbp:RefSeq NM_004382
gptkbp:signal_transduction_pathway gptkb:cAMP_pathway
gptkbp:transmembraneDomains 7
gptkbp:UniProtID gptkb:P34998
gptkbp:bfsParent gptkb:CRHR1
gptkb:CRHR1_protein
gptkbp:bfsLayer 7