|
gptkbp:instanceOf
|
gptkb:protein
gptkb:enzyme
|
|
gptkbp:activatedBy
|
gptkb:interleukin-18
inflammasome
interleukin-1 beta
|
|
gptkbp:associatedWith
|
gptkb:Alzheimer's_disease
gptkb:Crohn's_disease
sepsis
autoinflammatory diseases
|
|
gptkbp:cleavage
|
pro-IL-1β
pro-IL-18
|
|
gptkbp:discoveredBy
|
Yuan JY
|
|
gptkbp:EC_number
|
3.4.22.36
|
|
gptkbp:encodedBy
|
CASP1 gene
|
|
gptkbp:Entrez_Gene_ID
|
834
ENSG00000171453
|
|
gptkbp:expressedIn
|
dendritic cells
macrophages
monocytes
|
|
gptkbp:function
|
gptkb:protease
inflammatory response
cytokine maturation
|
|
gptkbp:GO_term
|
GO:0004197
|
|
gptkbp:HGNC_ID
|
HGNC:1504
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Caspase-1
|
|
gptkbp:inhibitedBy
|
caspase inhibitors
|
|
gptkbp:involvedIn
|
apoptosis
pyroptosis
|
|
gptkbp:locatedIn
|
cytosol
|
|
gptkbp:locatedOnChromosome
|
gptkb:human_chromosome_11
|
|
gptkbp:molecularWeight
|
45 kDa
|
|
gptkbp:OMIM
|
147678
|
|
gptkbp:orthologIn
|
mouse Casp1
rat Casp1
|
|
gptkbp:otherName
|
interleukin-1 beta converting enzyme
|
|
gptkbp:PDB
|
1ICE
|
|
gptkbp:proteinFamily
|
gptkb:PF00656
|
|
gptkbp:Reactome
|
R-HSA-448706
|
|
gptkbp:RefSeq
|
NP_150635.1
|
|
gptkbp:regulates
|
inflammation
cell death
|
|
gptkbp:species
|
gptkb:Mus_musculus
gptkb:Homo_sapiens
|
|
gptkbp:structure
|
heterotetramer
|
|
gptkbp:subunit
|
p10
p20
|
|
gptkbp:UniProtID
|
P29466
|
|
gptkbp:bfsParent
|
gptkb:Caspase
|
|
gptkbp:bfsLayer
|
7
|