Statements (53)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:biotechnology
genome editing technology molecular biology tool |
| gptkbp:appliesTo |
biomedical engineering
synthetic biology pharmaceutical development functional genomics crop improvement animal model creation human disease research |
| gptkbp:basedOn |
gptkb:CRISPR
gptkb:Cas9_protein |
| gptkbp:component |
gptkb:Cas9_endonuclease
gptkb:guide_RNA |
| gptkbp:controversy |
patent disputes
ethical concerns germline editing off-target effects |
| gptkbp:developedBy |
gptkb:Emmanuelle_Charpentier
gptkb:Jennifer_Doudna |
| gptkbp:enables |
gene knock-in
gene knock-out multiplexed gene editing targeted genome modification |
| gptkbp:firstPublished |
2012
|
| https://www.w3.org/2000/01/rdf-schema#label |
CRISPR-Cas9 technology
|
| gptkbp:mechanismOfAction |
induces double-strand breaks in DNA
relies on RNA-guided DNA targeting |
| gptkbp:NobelPrizeYear |
gptkb:Emmanuelle_Charpentier
gptkb:Jennifer_Doudna 2020 |
| gptkbp:notablePatentDispute |
University of California, Berkeley vs. Broad Institute
|
| gptkbp:regulates |
regulated by international agreements
regulated by national laws subject to bioethics guidelines |
| gptkbp:relatedTo |
gptkb:gene_drive
gptkb:CRISPR gptkb:Cas9 genome editing base editing prime editing |
| gptkbp:usedFor |
gptkb:agricultural_machinery
biomedical research gene editing genome engineering gene therapy disease modeling genetic research gene activation gene knockout gene repression |
| gptkbp:bfsParent |
gptkb:Caribou_Biosciences
|
| gptkbp:bfsLayer |
5
|