|
gptkbp:instanceOf
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gptkb:protein
|
|
gptkbp:alsoKnownAs
|
gptkb:Cpf1_family
|
|
gptkbp:cleavage
|
single-stranded DNA
double-stranded DNA
|
|
gptkbp:compatibleWith
|
gptkb:tracrRNA
|
|
gptkbp:discoveredIn
|
2015
|
|
gptkbp:firstCharacterized
|
gptkb:Acidaminococcus_sp._Cas12a
gptkb:Francisella_novicida_Cas12a
gptkb:Lachnospiraceae_bacterium_Cas12a
|
|
gptkbp:foundIn
|
gptkb:Bacteria
archaea
|
|
gptkbp:function
|
gptkb:DNA_endonuclease
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Cas12 family
|
|
gptkbp:mechanismOfAction
|
collateral cleavage activity
PAM-dependent DNA targeting
|
|
gptkbp:memberOf
|
gptkb:CRISPR-associated_proteins
|
|
gptkbp:recognizedBy
|
PAM sequence
|
|
gptkbp:relatedTo
|
gptkb:Cas9
|
|
gptkbp:requires
|
gptkb:crRNA
|
|
gptkbp:structure
|
gptkb:RuvC_domain
gptkb:REC_lobe
Bridge helix
Nuc domain
PI domain
WED domain
|
|
gptkbp:subspecies
|
gptkb:Cas12a
gptkb:Cas12b
gptkb:Cas12c
gptkb:Cas12d
gptkb:Cas12e
gptkb:Cas12f
gptkb:Cas12g
gptkb:Cas12h
gptkb:Cas12i
gptkb:Cas12j
gptkb:Cas12k
gptkb:Cas12l
gptkb:Cas12m
gptkb:Cas12n
gptkb:Cas12o
gptkb:Cas12p
gptkb:Cas12q
gptkb:Cas12r
gptkb:Cas12s
gptkb:Cas12t
gptkb:Cas12u
gptkb:Cas12v
gptkb:Cas12w
gptkb:Cas12x
gptkb:Cas12y
gptkb:Cas12z
|
|
gptkbp:usedIn
|
biosensing
diagnostics
genome editing
base editing
gene knock-in
gene knock-out
transcriptional regulation
|
|
gptkbp:bfsParent
|
gptkb:Cas12d
gptkb:Cas12e
gptkb:Cas12h
gptkb:Cas12m
gptkb:Cas12p
gptkb:Cas12q
gptkb:Cas12w
|
|
gptkbp:bfsLayer
|
7
|