stromal cell-derived factor 1
GPTKB entity
Statements (38)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
cytokine
|
| gptkbp:alsoKnownAs |
gptkb:SDF-1
gptkb:CXCL12 |
| gptkbp:binds |
CXCR4 receptor
CXCR7 receptor |
| gptkbp:category |
gptkb:protein
signaling molecule cytokine |
| gptkbp:discoveredBy |
T. Nagasawa et al.
|
| gptkbp:discoveredIn |
1994
|
| gptkbp:encodedBy |
gptkb:CXCL12_gene
|
| gptkbp:Entrez_Gene_ID |
6387
|
| gptkbp:foundIn |
humans
mice |
| gptkbp:function |
involved in angiogenesis
regulates hematopoiesis chemoattractant for lymphocytes involved in embryogenesis involved in immune surveillance |
| gptkbp:hasIsoform |
gptkb:SDF-1α
gptkb:SDF-1β gptkb:SDF-1γ |
| https://www.w3.org/2000/01/rdf-schema#label |
stromal cell-derived factor 1
|
| gptkbp:length |
89 amino acids (SDF-1α isoform)
|
| gptkbp:locatedOnChromosome |
gptkb:chromosome_10_(human)
|
| gptkbp:role |
HIV infection
cardiovascular diseases inflammatory diseases cancer metastasis stem cell homing |
| gptkbp:secretes |
endothelial cells
fibroblasts stromal cells osteoblasts |
| gptkbp:structure |
contains four conserved cysteine residues
|
| gptkbp:UniProtID |
gptkb:P48061
|
| gptkbp:bfsParent |
gptkb:CXCR4_co-receptor
|
| gptkbp:bfsLayer |
7
|