stromal cell-derived factor 1

URI: https://gptkb.org/entity/stromal_cell-derived_factor_1
GPTKB entity
Statements (39)
Predicate Object
gptkbp:instanceOf gptkb:cytokine
gptkbp:alsoKnownAs gptkb:SDF-1
gptkb:CXCL12
gptkbp:binds CXCR4 receptor
CXCR7 receptor
gptkbp:category gptkb:cytokine
gptkb:signaling_molecule
gptkb:protein
gptkbp:discoveredBy T. Nagasawa et al.
gptkbp:discoveredIn 1994
gptkbp:encodedBy gptkb:CXCL12_gene
gptkbp:Entrez_Gene_ID 6387
gptkbp:foundIn humans
mice
gptkbp:function involved in angiogenesis
regulates hematopoiesis
chemoattractant for lymphocytes
involved in embryogenesis
involved in immune surveillance
gptkbp:hasIsoform gptkb:SDF-1α
gptkb:SDF-1β
gptkb:SDF-1γ
gptkbp:length 89 amino acids (SDF-1α isoform)
gptkbp:locatedOnChromosome gptkb:chromosome_10_(human)
gptkbp:role HIV infection
cardiovascular diseases
inflammatory diseases
cancer metastasis
stem cell homing
gptkbp:secretes endothelial cells
fibroblasts
stromal cells
osteoblasts
gptkbp:structure contains four conserved cysteine residues
gptkbp:UniProtID gptkb:P48061
gptkbp:bfsParent gptkb:CXCR4_co-receptor
gptkb:CXCL12
gptkbp:bfsLayer 8
https://www.w3.org/2000/01/rdf-schema#label stromal cell-derived factor 1