Statements (50)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:gene
|
| gptkbp:alsoKnownAs |
gptkb:DDIT3
gptkb:GADD153 C/EBP homologous protein |
| gptkbp:associatedWith |
gptkb:cancer
gptkb:diabetes_mellitus neurodegenerative diseases unfolded protein response cellular stress response |
| gptkbp:downstreamOf |
ATF6 pathway
IRE1 pathway PERK pathway |
| gptkbp:encodes |
C/EBP homologous protein
|
| gptkbp:Entrez_Gene_ID |
1649
ENSG00000175197 |
| gptkbp:expressedIn |
various tissues
|
| gptkbp:firstDescribed |
1993
|
| gptkbp:function |
transcription factor
regulates apoptosis involved in endoplasmic reticulum stress response |
| gptkbp:HGNC_ID |
2736
|
| https://www.w3.org/2000/01/rdf-schema#label |
CHOP gene
|
| gptkbp:inducedBy |
oxidative stress
DNA damage endoplasmic reticulum stress |
| gptkbp:interactsWith |
gptkb:ATF4
C/EBPβ C/EBPα |
| gptkbp:involvedIn |
gptkb:integrated_stress_response
apoptotic signaling pathway |
| gptkbp:length |
169 amino acids
|
| gptkbp:locatedOnChromosome |
gptkb:chromosome_12
12q13.3 |
| gptkbp:molecularWeight |
~19 kDa
|
| gptkbp:mutationAssociatedWith |
tumorigenesis
metabolic disorders |
| gptkbp:OMIM |
603153
|
| gptkbp:orthologInMouse |
gptkb:Ddit3
|
| gptkbp:proteinFamily |
basic leucine zipper (bZIP) domain
|
| gptkbp:regulates |
gptkb:C/EBP_family
apoptosis cell cycle arrest cellular homeostasis expression of anti-apoptotic genes expression of pro-apoptotic genes transcription of stress response genes |
| gptkbp:subcellularLocation |
gptkb:nucleus
|
| gptkbp:UniProtID |
P35638
|
| gptkbp:bfsParent |
gptkb:Fused_in_Sarcoma_protein
|
| gptkbp:bfsLayer |
7
|