|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alsoKnownAs
|
gptkb:DDIT3
gptkb:GADD153
C/EBP homologous protein
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:diabetes_mellitus
gptkb:cellular_stress_response
neurodegenerative diseases
unfolded protein response
|
|
gptkbp:downstreamOf
|
ATF6 pathway
IRE1 pathway
PERK pathway
|
|
gptkbp:encodes
|
C/EBP homologous protein
|
|
gptkbp:Entrez_Gene_ID
|
1649
ENSG00000175197
|
|
gptkbp:expressedIn
|
various tissues
|
|
gptkbp:firstDescribed
|
1993
|
|
gptkbp:function
|
gptkb:transcription_factor
regulates apoptosis
involved in endoplasmic reticulum stress response
|
|
gptkbp:HGNC_ID
|
2736
|
|
gptkbp:inducedBy
|
oxidative stress
DNA damage
endoplasmic reticulum stress
|
|
gptkbp:interactsWith
|
gptkb:ATF4
C/EBPβ
C/EBPα
|
|
gptkbp:involvedIn
|
gptkb:integrated_stress_response
apoptotic signaling pathway
|
|
gptkbp:length
|
169 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_12
12q13.3
|
|
gptkbp:molecularWeight
|
~19 kDa
|
|
gptkbp:mutationAssociatedWith
|
tumorigenesis
metabolic disorders
|
|
gptkbp:OMIM
|
603153
|
|
gptkbp:orthologInMouse
|
gptkb:Ddit3
|
|
gptkbp:proteinFamily
|
basic leucine zipper (bZIP) domain
|
|
gptkbp:regulates
|
gptkb:C/EBP_family
apoptosis
cell cycle arrest
cellular homeostasis
expression of anti-apoptotic genes
expression of pro-apoptotic genes
transcription of stress response genes
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
|
|
gptkbp:UniProtID
|
P35638
|
|
gptkbp:bfsParent
|
gptkb:Fused_in_Sarcoma_protein
|
|
gptkbp:bfsLayer
|
7
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
CHOP gene
|