Statements (25)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
genetic disorder
|
| gptkbp:affects |
CCR5 gene
|
| gptkbp:alleleFrequencyHighIn |
Northern European populations
|
| gptkbp:alleleFrequencyLowIn |
gptkb:East_Asian_populations
gptkb:African_populations |
| gptkbp:associatedWith |
increased risk of West Nile virus infection
increased risk of severe influenza |
| gptkbp:cause |
truncated CCR5 protein
|
| gptkbp:discoveredIn |
1996
|
| gptkbp:heterozygousIndividualsAre |
partially resistant to HIV-1
|
| gptkbp:homozygousIndividualsAre |
highly resistant to HIV-1
|
| https://www.w3.org/2000/01/rdf-schema#label |
CCR5-Δ32
|
| gptkbp:inheritsFrom |
autosomal recessive trait
|
| gptkbp:lengthOfDeletion |
32 base pairs
|
| gptkbp:locatedOnChromosome |
chromosome 3p21
|
| gptkbp:mutationAssociatedWith |
deletion
|
| gptkbp:notableFor |
Berlin patient
London patient |
| gptkbp:resistantTo |
HIV-1 infection
|
| gptkbp:result |
nonfunctional CCR5 receptor
|
| gptkbp:usedIn |
HIV cure research
|
| gptkbp:bfsParent |
gptkb:rs113488022
gptkb:CCR5 gptkb:CCR5_co-receptor |
| gptkbp:bfsLayer |
7
|