gptkbp:instanceOf
|
gptkb:G_protein-coupled_receptor
cannabinoid receptor
|
gptkbp:activatedBy
|
gptkb:THC
gptkb:2-arachidonoylglycerol
gptkb:anandamide
|
gptkbp:alternativeName
|
gptkb:CNR1
Cannabinoid receptor type 1
|
gptkbp:discoveredIn
|
1990
|
gptkbp:encodedBy
|
gptkb:CNR1_gene
|
gptkbp:enemyOf
|
gptkb:THC
gptkb:2-AG
gptkb:SR141716A
gptkb:anandamide
gptkb:rimonabant
gptkb:AM251
|
gptkbp:expressedIn
|
gptkb:oligodendrocytes
neurons
astrocytes
|
gptkbp:foundIn
|
gptkb:skeletal_muscle
brain
gastrointestinal tract
central nervous system
liver
adipose tissue
peripheral nervous system
reproductive organs
|
gptkbp:function
|
memory
motor control
mood regulation
modulation of neurotransmitter release
pain sensation
regulation of appetite
|
https://www.w3.org/2000/01/rdf-schema#label
|
CB1 receptor
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_6
|
gptkbp:molecularWeight
|
53 kDa
|
gptkbp:OMIM
|
114610
|
gptkbp:relatedTo
|
gptkb:CB2_receptor
|
gptkbp:significance
|
target for anti-obesity drugs
target for neurodegenerative disease therapy
target for pain management
target for psychiatric disorder treatment
|
gptkbp:structure
|
seven transmembrane domains
|
gptkbp:type
|
activation of MAP kinase pathway
inhibition of adenylate cyclase
modulation of ion channels
|
gptkbp:UniProtID
|
gptkb:P21554
|
gptkbp:bfsParent
|
gptkb:JWH_cannabinoids
gptkb:endocannabinoid_system
gptkb:CB1_receptor_(indirect)
gptkb:D8
gptkb:THC
|
gptkbp:bfsLayer
|
6
|