|
gptkbp:instanceOf
|
antibiotic class
|
|
gptkbp:ATCCode
|
gptkb:J01C
|
|
gptkbp:chemicalStructureFeature
|
four-membered lactam ring
|
|
gptkbp:concerns
|
antibiotic resistance
|
|
gptkbp:contains
|
beta-lactam ring
|
|
gptkbp:contraindication
|
penicillin allergy
|
|
gptkbp:discoveredBy
|
gptkb:Alexander_Fleming
1928
|
|
gptkbp:drugInteraction
|
gptkb:probenecid
oral contraceptives
|
|
gptkbp:example
|
gptkb:amoxicillin
gptkb:penicillin_G
gptkb:aztreonam
gptkb:ceftriaxone
gptkb:imipenem
|
|
gptkbp:excretion
|
gptkb:kidney
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Beta-lactam antibiotics
|
|
gptkbp:mechanismOfAction
|
inhibit bacterial cell wall synthesis
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:origin
|
gptkb:Bacteria
fungi
semisynthetic
|
|
gptkbp:pregnancyCategory
|
varies by drug
|
|
gptkbp:resistantTo
|
beta-lactamase production
|
|
gptkbp:routeOfAdministration
|
oral
intramuscular
intravenous
|
|
gptkbp:sideEffect
|
diarrhea
allergic reaction
rash
|
|
gptkbp:spectrumOfActivity
|
broad-spectrum
narrow-spectrum
|
|
gptkbp:subclassOf
|
gptkb:cephalosporins
gptkb:monobactams
penicillins
carbapenems
|
|
gptkbp:target
|
penicillin-binding proteins
|
|
gptkbp:usedFor
|
bacterial infections
|
|
gptkbp:usedIn
|
gptkb:veterinary_medicine
human medicine
|
|
gptkbp:WHOModelListOfEssentialMedicines
|
true
|
|
gptkbp:bfsParent
|
gptkb:MRSA_infections
gptkb:MRSA_infection
|
|
gptkbp:bfsLayer
|
7
|