|
gptkbp:instance_of
|
gptkb:pharmaceuticals
|
|
gptkbp:activities
|
narrow spectrum
|
|
gptkbp:administered_by
|
injection
|
|
gptkbp:approves
|
gptkb:animals
gptkb:humans
|
|
gptkbp:chemical_formula
|
C16 H18 N2 O5 S
|
|
gptkbp:class
|
beta-lactam antibiotic
|
|
gptkbp:clinical_trial
|
ongoing
|
|
gptkbp:composed_by
|
gptkb:penicillin
|
|
gptkbp:contraindication
|
penicillin allergy
|
|
gptkbp:developed_by
|
gptkb:Howard_Florey
|
|
gptkbp:discovered_by
|
gptkb:Alexander_Fleming
|
|
gptkbp:discovery_year
|
1928
|
|
gptkbp:first_introduced
|
gptkb:World_War_II
|
|
gptkbp:formulation
|
potassium salt
sodium salt
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
penicillin G
|
|
gptkbp:interacts_with
|
gptkb:methotrexate
probenecid
|
|
gptkbp:invention
|
expired
|
|
gptkbp:is_effective_against
|
gptkb:Streptococcus_pneumoniae
gptkb:Staphylococcus_aureus
viral infections
Neisseria meningitidis
mycobacterial infections
|
|
gptkbp:is_used_for
|
bacterial infections
|
|
gptkbp:lifespan
|
30 minutes to 1 hour
|
|
gptkbp:marketed_as
|
Pfizerpen
|
|
gptkbp:mechanism_of_action
|
inhibits cell wall synthesis
|
|
gptkbp:produced_by
|
gptkb:yeast
|
|
gptkbp:replaces
|
gptkb:Penicillium_chrysogenum
|
|
gptkbp:research_areas
|
gptkb:disease
gptkb:rheumatic_fever
gptkb:pneumonia
meningitis
sepsis
skin infections
endocarditis
bone infections
gas gangrene
joint infections
|
|
gptkbp:resistance_mechanisms
|
beta-lactamase production
altered penicillin-binding proteins
|
|
gptkbp:rounds
|
renal
|
|
gptkbp:route_of_administration
|
intravenous
|
|
gptkbp:sensitivity
|
broth microdilution method
disk diffusion method
|
|
gptkbp:side_effect
|
allergic reactions
|
|
gptkbp:storage
|
refrigerated
|
|
gptkbp:trade
|
Bicillin
|
|
gptkbp:bfsParent
|
gptkb:penicillin
|
|
gptkbp:bfsLayer
|
5
|