Navitoclax

GPTKB entity

Statements (33)
Predicate Object
gptkbp:instanceOf gptkb:drug
small molecule
gptkbp:ATCCode L01XX52
gptkbp:CASNumber 923564-51-6
gptkbp:clinicalTrialPhase Phase II
gptkbp:developedBy gptkb:AbbVie
gptkb:Genentech
gptkbp:firstDescribed 2008
gptkbp:hasMolecularFormula C47H55ClN6O10S
gptkbp:hasPatent US20080275142A1
gptkbp:hasSMILES CC1=C(C=C(C=C1)N2CCN(CC2)C(=O)COC3=CC=CC=C3)C4=CC=C(C=C4)C(=O)NCC5=CC=CC=C5
https://www.w3.org/2000/01/rdf-schema#label Navitoclax
gptkbp:legalStatus investigational
gptkbp:mechanismOfAction Bcl-xL inhibitor
Bcl-2 inhibitor
gptkbp:molecularWeight 974.5 g/mol
gptkbp:PubChem_CID gptkb:DB11707
11522607
CHEMBL452195
gptkbp:routeOfAdministration oral
gptkbp:sideEffect gptkb:anemia
neutropenia
thrombocytopenia
gptkbp:synonym ABT-263
gptkbp:target gptkb:BCL2
gptkb:BCL2L1
gptkb:BCL2L2
gptkbp:UNII K1DI23H2PW
gptkbp:usedFor gptkb:cancer
chronic lymphocytic leukemia
solid tumors (investigational)
gptkbp:bfsParent gptkb:Bcl-xL
gptkbp:bfsLayer 7